Abstract
Both selective and nonselective cyclooxygenase (COX) inhibitors can reduce potassium excretion and can produce or exacerbate hyperkalemia.1-12 We investigated whether there is a difference between the effects of nonselective COX-1/COX-2 inhibitors and selective COX-2 inhibitors on provoked dynamic renal potassium excretion. We apply a mixed-effects model statistical approach that allows investigation of druginduced delays in reaching maximal potassium excretion, blunting/flattening of potassium handling curves, and shift/separation in potassium handling at peak potassium excretion.
Original language | English (US) |
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Pages (from-to) | 208-211 |
Number of pages | 4 |
Journal | Clinical Pharmacology and Therapeutics |
Volume | 84 |
Issue number | 2 |
DOIs | |
State | Published - Aug 1 2008 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)