Effects of selective vs. nonselective cyclooxygenase inhibition on dynamic renal potassium excretion: A randomized trial

R. A. Preston, D. Afshartous, A. B. Alonso

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Both selective and nonselective cyclooxygenase (COX) inhibitors can reduce potassium excretion and can produce or exacerbate hyperkalemia.1-12 We investigated whether there is a difference between the effects of nonselective COX-1/COX-2 inhibitors and selective COX-2 inhibitors on provoked dynamic renal potassium excretion. We apply a mixed-effects model statistical approach that allows investigation of druginduced delays in reaching maximal potassium excretion, blunting/flattening of potassium handling curves, and shift/separation in potassium handling at peak potassium excretion.

Original languageEnglish (US)
Pages (from-to)208-211
Number of pages4
JournalClinical Pharmacology and Therapeutics
Volume84
Issue number2
DOIs
StatePublished - Aug 1 2008

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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