Effects of selective vs. nonselective cyclooxygenase inhibition on dynamic renal potassium excretion: A randomized trial

Both selective and nonselective cyclooxygenase (COX) inhibitors can reduce potassium excretion and can produce or exacerbate hyperkalemia.^1-12 We investigated whether there is a difference between the effects of nonselective COX-1/COX-2 inhibitors and selective COX-2 inhibitors on provoked dynamic renal potassium excretion. We apply a mixed-effects model statistical approach that allows investigation of druginduced delays in reaching maximal potassium excretion, blunting/flattening of potassium handling curves, and shift/separation in potassium handling at peak potassium excretion.