Effects of repeated Valsalva maneuver straining on cardiac and vasoconstrictive baroreflex responses

Victor A. Convertino, Duane A. Ratliff, Donald F. Doerr, David A. Ludwig, Gary W. Muniz, Erik Benedetti, Jose Chavarria, Susan Koreen, Claude Nguyen, Jeff Wang

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Introduction: We hypothesized that repeated respiratory straining maneuvers (repeated SM) designed to elevate arterial BPs (arterial baroreceptor loading) would acutely increase baroreflex responses. Methods: We tested this hypothesis by measuring cardiac baroreflex responses to carotid baroreceptor stimulation (neck pressures), and changes in heart rate and diastolic BP after reductions in BP induced by a 15-s Valsalva maneuver in 10 female and 10 male subjects at 1, 3, 6, and 24 h after performing repeated SM. Baroreflex responses were also measured in each subject at 1, 3, 6, and 24 h at the same time on a separate day without repeated SM (control) in a randomized, counter-balanced cross-over experimental design. Results: There was no statistical difference in carotid-cardiac and peripheral vascular baroreflex responses measured across time following repeated SM compared with the control condition. Integrated cardiac baroreflex response (ΔHR/ ASBP) measured during performance of a Valsalva maneuver was increased by approximately 50% to 1.1 ± 0.2 bpm · mm Hg-1 at 1 h and 1.0 ± 0.1 bpm · mm Hg-1 at 3 h following repeated SM compared with the control condition (0.7 ± 0.1 bpm · mm Hg-1 at both 1 and 3 h, respectively). However, integrated cardiac baroreflex response after repeated SM returned to control levels at 6 and 24 h after training. These responses did not differ between men and women. Conclusions: Our results are consistent with the notion that arterial baroreceptor loading induced by repeated SM increased aortic, but not carotid, cardiac baroreflex responses for as long as 3 h after repeated SM. We conclude that repeated SM increases cardiac baroreflex responsiveness which may provide patients, astronauts, and high-performance aircraft pilots with protection from development of orthostatic hypotension.

Original languageEnglish (US)
Pages (from-to)212-219
Number of pages8
JournalAviation Space and Environmental Medicine
Volume74
Issue number3
StatePublished - Mar 1 2003

Keywords

  • Baroreceptors
  • Heart rate
  • Valsalva maneuver
  • Vasoconstriction

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Pollution
  • Medicine(all)

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  • Cite this

    Convertino, V. A., Ratliff, D. A., Doerr, D. F., Ludwig, D. A., Muniz, G. W., Benedetti, E., Chavarria, J., Koreen, S., Nguyen, C., & Wang, J. (2003). Effects of repeated Valsalva maneuver straining on cardiac and vasoconstrictive baroreflex responses. Aviation Space and Environmental Medicine, 74(3), 212-219.