Abstract
Introduction: We hypothesized that repeated respiratory straining maneuvers (repeated SM) designed to elevate arterial BPs (arterial baroreceptor loading) would acutely increase baroreflex responses. Methods: We tested this hypothesis by measuring cardiac baroreflex responses to carotid baroreceptor stimulation (neck pressures), and changes in heart rate and diastolic BP after reductions in BP induced by a 15-s Valsalva maneuver in 10 female and 10 male subjects at 1, 3, 6, and 24 h after performing repeated SM. Baroreflex responses were also measured in each subject at 1, 3, 6, and 24 h at the same time on a separate day without repeated SM (control) in a randomized, counter-balanced cross-over experimental design. Results: There was no statistical difference in carotid-cardiac and peripheral vascular baroreflex responses measured across time following repeated SM compared with the control condition. Integrated cardiac baroreflex response (ΔHR/ ASBP) measured during performance of a Valsalva maneuver was increased by approximately 50% to 1.1 ± 0.2 bpm · mm Hg-1 at 1 h and 1.0 ± 0.1 bpm · mm Hg-1 at 3 h following repeated SM compared with the control condition (0.7 ± 0.1 bpm · mm Hg-1 at both 1 and 3 h, respectively). However, integrated cardiac baroreflex response after repeated SM returned to control levels at 6 and 24 h after training. These responses did not differ between men and women. Conclusions: Our results are consistent with the notion that arterial baroreceptor loading induced by repeated SM increased aortic, but not carotid, cardiac baroreflex responses for as long as 3 h after repeated SM. We conclude that repeated SM increases cardiac baroreflex responsiveness which may provide patients, astronauts, and high-performance aircraft pilots with protection from development of orthostatic hypotension.
| Original language | English |
|---|---|
| Pages (from-to) | 212-219 |
| Number of pages | 8 |
| Journal | Aviation Space and Environmental Medicine |
| Volume | 74 |
| Issue number | 3 |
| State | Published - Mar 1 2003 |
| Externally published | Yes |
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Keywords
- Baroreceptors
- Heart rate
- Valsalva maneuver
- Vasoconstriction
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Pollution
- Medicine(all)
Cite this
Effects of repeated Valsalva maneuver straining on cardiac and vasoconstrictive baroreflex responses. / Convertino, Victor A.; Ratliff, Duane A.; Doerr, Donald F.; Ludwig, David; Muniz, Gary W.; Benedetti, Erik; Chavarria, Jose; Koreen, Susan; Nguyen, Claude; Wang, Jeff.
In: Aviation Space and Environmental Medicine, Vol. 74, No. 3, 01.03.2003, p. 212-219.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of repeated Valsalva maneuver straining on cardiac and vasoconstrictive baroreflex responses
AU - Convertino, Victor A.
AU - Ratliff, Duane A.
AU - Doerr, Donald F.
AU - Ludwig, David
AU - Muniz, Gary W.
AU - Benedetti, Erik
AU - Chavarria, Jose
AU - Koreen, Susan
AU - Nguyen, Claude
AU - Wang, Jeff
PY - 2003/3/1
Y1 - 2003/3/1
N2 - Introduction: We hypothesized that repeated respiratory straining maneuvers (repeated SM) designed to elevate arterial BPs (arterial baroreceptor loading) would acutely increase baroreflex responses. Methods: We tested this hypothesis by measuring cardiac baroreflex responses to carotid baroreceptor stimulation (neck pressures), and changes in heart rate and diastolic BP after reductions in BP induced by a 15-s Valsalva maneuver in 10 female and 10 male subjects at 1, 3, 6, and 24 h after performing repeated SM. Baroreflex responses were also measured in each subject at 1, 3, 6, and 24 h at the same time on a separate day without repeated SM (control) in a randomized, counter-balanced cross-over experimental design. Results: There was no statistical difference in carotid-cardiac and peripheral vascular baroreflex responses measured across time following repeated SM compared with the control condition. Integrated cardiac baroreflex response (ΔHR/ ASBP) measured during performance of a Valsalva maneuver was increased by approximately 50% to 1.1 ± 0.2 bpm · mm Hg-1 at 1 h and 1.0 ± 0.1 bpm · mm Hg-1 at 3 h following repeated SM compared with the control condition (0.7 ± 0.1 bpm · mm Hg-1 at both 1 and 3 h, respectively). However, integrated cardiac baroreflex response after repeated SM returned to control levels at 6 and 24 h after training. These responses did not differ between men and women. Conclusions: Our results are consistent with the notion that arterial baroreceptor loading induced by repeated SM increased aortic, but not carotid, cardiac baroreflex responses for as long as 3 h after repeated SM. We conclude that repeated SM increases cardiac baroreflex responsiveness which may provide patients, astronauts, and high-performance aircraft pilots with protection from development of orthostatic hypotension.
AB - Introduction: We hypothesized that repeated respiratory straining maneuvers (repeated SM) designed to elevate arterial BPs (arterial baroreceptor loading) would acutely increase baroreflex responses. Methods: We tested this hypothesis by measuring cardiac baroreflex responses to carotid baroreceptor stimulation (neck pressures), and changes in heart rate and diastolic BP after reductions in BP induced by a 15-s Valsalva maneuver in 10 female and 10 male subjects at 1, 3, 6, and 24 h after performing repeated SM. Baroreflex responses were also measured in each subject at 1, 3, 6, and 24 h at the same time on a separate day without repeated SM (control) in a randomized, counter-balanced cross-over experimental design. Results: There was no statistical difference in carotid-cardiac and peripheral vascular baroreflex responses measured across time following repeated SM compared with the control condition. Integrated cardiac baroreflex response (ΔHR/ ASBP) measured during performance of a Valsalva maneuver was increased by approximately 50% to 1.1 ± 0.2 bpm · mm Hg-1 at 1 h and 1.0 ± 0.1 bpm · mm Hg-1 at 3 h following repeated SM compared with the control condition (0.7 ± 0.1 bpm · mm Hg-1 at both 1 and 3 h, respectively). However, integrated cardiac baroreflex response after repeated SM returned to control levels at 6 and 24 h after training. These responses did not differ between men and women. Conclusions: Our results are consistent with the notion that arterial baroreceptor loading induced by repeated SM increased aortic, but not carotid, cardiac baroreflex responses for as long as 3 h after repeated SM. We conclude that repeated SM increases cardiac baroreflex responsiveness which may provide patients, astronauts, and high-performance aircraft pilots with protection from development of orthostatic hypotension.
KW - Baroreceptors
KW - Heart rate
KW - Valsalva maneuver
KW - Vasoconstriction
UR - http://www.scopus.com/inward/record.url?scp=0037335693&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037335693&partnerID=8YFLogxK
M3 - Article
C2 - 12650267
AN - SCOPUS:0037335693
VL - 74
SP - 212
EP - 219
JO - Aerospace medicine and human performance
JF - Aerospace medicine and human performance
SN - 2375-6314
IS - 3
ER -