Effects of repeated Valsalva maneuver straining on cardiac and vasoconstrictive baroreflex responses

Victor A. Convertino, Duane A. Ratliff, Donald F. Doerr, David Ludwig, Gary W. Muniz, Erik Benedetti, Jose Chavarria, Susan Koreen, Claude Nguyen, Jeff Wang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Introduction: We hypothesized that repeated respiratory straining maneuvers (repeated SM) designed to elevate arterial BPs (arterial baroreceptor loading) would acutely increase baroreflex responses. Methods: We tested this hypothesis by measuring cardiac baroreflex responses to carotid baroreceptor stimulation (neck pressures), and changes in heart rate and diastolic BP after reductions in BP induced by a 15-s Valsalva maneuver in 10 female and 10 male subjects at 1, 3, 6, and 24 h after performing repeated SM. Baroreflex responses were also measured in each subject at 1, 3, 6, and 24 h at the same time on a separate day without repeated SM (control) in a randomized, counter-balanced cross-over experimental design. Results: There was no statistical difference in carotid-cardiac and peripheral vascular baroreflex responses measured across time following repeated SM compared with the control condition. Integrated cardiac baroreflex response (ΔHR/ ASBP) measured during performance of a Valsalva maneuver was increased by approximately 50% to 1.1 ± 0.2 bpm · mm Hg-1 at 1 h and 1.0 ± 0.1 bpm · mm Hg-1 at 3 h following repeated SM compared with the control condition (0.7 ± 0.1 bpm · mm Hg-1 at both 1 and 3 h, respectively). However, integrated cardiac baroreflex response after repeated SM returned to control levels at 6 and 24 h after training. These responses did not differ between men and women. Conclusions: Our results are consistent with the notion that arterial baroreceptor loading induced by repeated SM increased aortic, but not carotid, cardiac baroreflex responses for as long as 3 h after repeated SM. We conclude that repeated SM increases cardiac baroreflex responsiveness which may provide patients, astronauts, and high-performance aircraft pilots with protection from development of orthostatic hypotension.

Original languageEnglish
Pages (from-to)212-219
Number of pages8
JournalAviation Space and Environmental Medicine
Volume74
Issue number3
StatePublished - Mar 1 2003
Externally publishedYes

Fingerprint

Valsalva Maneuver
Baroreflex
Pressoreceptors
Level control
Design of experiments
Aircraft
Astronauts
Orthostatic Hypotension
Cross-Over Studies
Blood Vessels
Research Design
Neck
Heart Rate
Pressure

Keywords

  • Baroreceptors
  • Heart rate
  • Valsalva maneuver
  • Vasoconstriction

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Pollution
  • Medicine(all)

Cite this

Convertino, V. A., Ratliff, D. A., Doerr, D. F., Ludwig, D., Muniz, G. W., Benedetti, E., ... Wang, J. (2003). Effects of repeated Valsalva maneuver straining on cardiac and vasoconstrictive baroreflex responses. Aviation Space and Environmental Medicine, 74(3), 212-219.

Effects of repeated Valsalva maneuver straining on cardiac and vasoconstrictive baroreflex responses. / Convertino, Victor A.; Ratliff, Duane A.; Doerr, Donald F.; Ludwig, David; Muniz, Gary W.; Benedetti, Erik; Chavarria, Jose; Koreen, Susan; Nguyen, Claude; Wang, Jeff.

In: Aviation Space and Environmental Medicine, Vol. 74, No. 3, 01.03.2003, p. 212-219.

Research output: Contribution to journalArticle

Convertino, VA, Ratliff, DA, Doerr, DF, Ludwig, D, Muniz, GW, Benedetti, E, Chavarria, J, Koreen, S, Nguyen, C & Wang, J 2003, 'Effects of repeated Valsalva maneuver straining on cardiac and vasoconstrictive baroreflex responses', Aviation Space and Environmental Medicine, vol. 74, no. 3, pp. 212-219.
Convertino VA, Ratliff DA, Doerr DF, Ludwig D, Muniz GW, Benedetti E et al. Effects of repeated Valsalva maneuver straining on cardiac and vasoconstrictive baroreflex responses. Aviation Space and Environmental Medicine. 2003 Mar 1;74(3):212-219.
Convertino, Victor A. ; Ratliff, Duane A. ; Doerr, Donald F. ; Ludwig, David ; Muniz, Gary W. ; Benedetti, Erik ; Chavarria, Jose ; Koreen, Susan ; Nguyen, Claude ; Wang, Jeff. / Effects of repeated Valsalva maneuver straining on cardiac and vasoconstrictive baroreflex responses. In: Aviation Space and Environmental Medicine. 2003 ; Vol. 74, No. 3. pp. 212-219.
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AU - Ludwig, David

AU - Muniz, Gary W.

AU - Benedetti, Erik

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N2 - Introduction: We hypothesized that repeated respiratory straining maneuvers (repeated SM) designed to elevate arterial BPs (arterial baroreceptor loading) would acutely increase baroreflex responses. Methods: We tested this hypothesis by measuring cardiac baroreflex responses to carotid baroreceptor stimulation (neck pressures), and changes in heart rate and diastolic BP after reductions in BP induced by a 15-s Valsalva maneuver in 10 female and 10 male subjects at 1, 3, 6, and 24 h after performing repeated SM. Baroreflex responses were also measured in each subject at 1, 3, 6, and 24 h at the same time on a separate day without repeated SM (control) in a randomized, counter-balanced cross-over experimental design. Results: There was no statistical difference in carotid-cardiac and peripheral vascular baroreflex responses measured across time following repeated SM compared with the control condition. Integrated cardiac baroreflex response (ΔHR/ ASBP) measured during performance of a Valsalva maneuver was increased by approximately 50% to 1.1 ± 0.2 bpm · mm Hg-1 at 1 h and 1.0 ± 0.1 bpm · mm Hg-1 at 3 h following repeated SM compared with the control condition (0.7 ± 0.1 bpm · mm Hg-1 at both 1 and 3 h, respectively). However, integrated cardiac baroreflex response after repeated SM returned to control levels at 6 and 24 h after training. These responses did not differ between men and women. Conclusions: Our results are consistent with the notion that arterial baroreceptor loading induced by repeated SM increased aortic, but not carotid, cardiac baroreflex responses for as long as 3 h after repeated SM. We conclude that repeated SM increases cardiac baroreflex responsiveness which may provide patients, astronauts, and high-performance aircraft pilots with protection from development of orthostatic hypotension.

AB - Introduction: We hypothesized that repeated respiratory straining maneuvers (repeated SM) designed to elevate arterial BPs (arterial baroreceptor loading) would acutely increase baroreflex responses. Methods: We tested this hypothesis by measuring cardiac baroreflex responses to carotid baroreceptor stimulation (neck pressures), and changes in heart rate and diastolic BP after reductions in BP induced by a 15-s Valsalva maneuver in 10 female and 10 male subjects at 1, 3, 6, and 24 h after performing repeated SM. Baroreflex responses were also measured in each subject at 1, 3, 6, and 24 h at the same time on a separate day without repeated SM (control) in a randomized, counter-balanced cross-over experimental design. Results: There was no statistical difference in carotid-cardiac and peripheral vascular baroreflex responses measured across time following repeated SM compared with the control condition. Integrated cardiac baroreflex response (ΔHR/ ASBP) measured during performance of a Valsalva maneuver was increased by approximately 50% to 1.1 ± 0.2 bpm · mm Hg-1 at 1 h and 1.0 ± 0.1 bpm · mm Hg-1 at 3 h following repeated SM compared with the control condition (0.7 ± 0.1 bpm · mm Hg-1 at both 1 and 3 h, respectively). However, integrated cardiac baroreflex response after repeated SM returned to control levels at 6 and 24 h after training. These responses did not differ between men and women. Conclusions: Our results are consistent with the notion that arterial baroreceptor loading induced by repeated SM increased aortic, but not carotid, cardiac baroreflex responses for as long as 3 h after repeated SM. We conclude that repeated SM increases cardiac baroreflex responsiveness which may provide patients, astronauts, and high-performance aircraft pilots with protection from development of orthostatic hypotension.

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