Effects of recent sexual activity and use of a diaphragm on the vaginal microflora

Thomas Hooton, Pacita L. Roberts, Walter E. Stamm

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

We prospectively studied 40 women over a median period of 28 weeks to ascertain the effects on vaginal microflora of sexual intercourse alone compared with sexual intercourse associated with use of a diaphragm with a spermicide (diaphragm/spermicide). Compared with no sexual intercourse, sexual intercourse with use of a diaphragm/spermicide in the preceding 3 days was strongly associated with increases in rates of vaginal colonization with uropathogenic flora, including Escherichia coli (P < .0001), other gram- negative uropathogens (P = .0045), group D streptococci (P = .014), and group B streptococci (P = .0015). Except for E. coli colonization, no such increases in rates of vaginal colonization were seen at visits preceded by sexual intercourse without use of a diaphragm/spermicide. Compared with no sexual intercourse, sexual intercourse with use of a diaphragm/spermicide in the preceding 3 days also was associated with a marked increase in rates of candidal colonization (P < .0001) and with a decrease in rates of lactobacillus colonization (P < .0001). We conclude that bacterial and fungal microflora in the vagina are strongly influenced by recent use of a diaphragm/spermicide and minimally affected by sexual intercourse alone.

Original languageEnglish
Pages (from-to)274-278
Number of pages5
JournalClinical Infectious Diseases
Volume19
Issue number2
StatePublished - Aug 1 1994
Externally publishedYes

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Female Contraceptive Devices
Coitus
Sexual Behavior
Diaphragm
Escherichia coli
Streptococcus agalactiae
Enterococcus faecalis
Lactobacillus
Vagina

ASJC Scopus subject areas

  • Immunology

Cite this

Effects of recent sexual activity and use of a diaphragm on the vaginal microflora. / Hooton, Thomas; Roberts, Pacita L.; Stamm, Walter E.

In: Clinical Infectious Diseases, Vol. 19, No. 2, 01.08.1994, p. 274-278.

Research output: Contribution to journalArticle

Hooton, Thomas ; Roberts, Pacita L. ; Stamm, Walter E. / Effects of recent sexual activity and use of a diaphragm on the vaginal microflora. In: Clinical Infectious Diseases. 1994 ; Vol. 19, No. 2. pp. 274-278.
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