Effects of rate (0.3-40/s) on simultaneously recorded auditory brainstem, middle and late responses using deconvolution

Fred Holt, Ozcan Ozdamar

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: Auditory evoked potentials (AEPs) are typically acquired in either transient (low-rate) or steady state (high-rate) conditions. This study utilizes deconvolution to obtain transient responses over a range of rates from 0.3 to 40/s, to establish a rate profile of transient responses employing uniform recording conditions. Methods: Deconvolution is used to obtain transient responses from quasi steady state recordings for rates 3.5-40/s, and components are scored and waveform morphologies are compared across rates. Results: All component latencies remain stable across all rates other than P2, which decreases for rates up to 3.5/s. Amplitudes for brainstem (V, Na), middle latency (Pa, Nb), and late (Pb/P1, N1 and P2) responses increased for rates below 1, 2 and 3.5/s, respectively. Rates between 3.5 and 25/s undergo a gradual morphology transition, above which oscillations begin to occur after 100 ms. Conclusions: Auditory brainstem, middle and late latency components other than P2 show stable latencies across 0.3-40/s with varying amplitude rate dependencies. Significance: Obtaining a transient response rate profile utilizing uniform acquisition parameters is useful for an improved understanding of how individual AEP components interact with stimulation rate, and can provide a more comprehensive assessment of the ascending auditory pathway and primary auditory cortices.

Original languageEnglish (US)
Pages (from-to)1589-1602
Number of pages14
JournalClinical Neurophysiology
Volume127
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Auditory Evoked Potentials
Brain Stem
Auditory Pathways
Auditory Cortex

Keywords

  • Adaptation
  • Auditory evoked potentials
  • Chirp
  • Deconvolution
  • Rate effects
  • Transient response

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Cite this

Effects of rate (0.3-40/s) on simultaneously recorded auditory brainstem, middle and late responses using deconvolution. / Holt, Fred; Ozdamar, Ozcan.

In: Clinical Neurophysiology, Vol. 127, No. 2, 01.02.2016, p. 1589-1602.

Research output: Contribution to journalArticle

@article{516774ff34414bb7aec8f0e8730f5f48,
title = "Effects of rate (0.3-40/s) on simultaneously recorded auditory brainstem, middle and late responses using deconvolution",
abstract = "Objective: Auditory evoked potentials (AEPs) are typically acquired in either transient (low-rate) or steady state (high-rate) conditions. This study utilizes deconvolution to obtain transient responses over a range of rates from 0.3 to 40/s, to establish a rate profile of transient responses employing uniform recording conditions. Methods: Deconvolution is used to obtain transient responses from quasi steady state recordings for rates 3.5-40/s, and components are scored and waveform morphologies are compared across rates. Results: All component latencies remain stable across all rates other than P2, which decreases for rates up to 3.5/s. Amplitudes for brainstem (V, Na), middle latency (Pa, Nb), and late (Pb/P1, N1 and P2) responses increased for rates below 1, 2 and 3.5/s, respectively. Rates between 3.5 and 25/s undergo a gradual morphology transition, above which oscillations begin to occur after 100 ms. Conclusions: Auditory brainstem, middle and late latency components other than P2 show stable latencies across 0.3-40/s with varying amplitude rate dependencies. Significance: Obtaining a transient response rate profile utilizing uniform acquisition parameters is useful for an improved understanding of how individual AEP components interact with stimulation rate, and can provide a more comprehensive assessment of the ascending auditory pathway and primary auditory cortices.",
keywords = "Adaptation, Auditory evoked potentials, Chirp, Deconvolution, Rate effects, Transient response",
author = "Fred Holt and Ozcan Ozdamar",
year = "2016",
month = "2",
day = "1",
doi = "10.1016/j.clinph.2015.10.046",
language = "English (US)",
volume = "127",
pages = "1589--1602",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Effects of rate (0.3-40/s) on simultaneously recorded auditory brainstem, middle and late responses using deconvolution

AU - Holt, Fred

AU - Ozdamar, Ozcan

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Objective: Auditory evoked potentials (AEPs) are typically acquired in either transient (low-rate) or steady state (high-rate) conditions. This study utilizes deconvolution to obtain transient responses over a range of rates from 0.3 to 40/s, to establish a rate profile of transient responses employing uniform recording conditions. Methods: Deconvolution is used to obtain transient responses from quasi steady state recordings for rates 3.5-40/s, and components are scored and waveform morphologies are compared across rates. Results: All component latencies remain stable across all rates other than P2, which decreases for rates up to 3.5/s. Amplitudes for brainstem (V, Na), middle latency (Pa, Nb), and late (Pb/P1, N1 and P2) responses increased for rates below 1, 2 and 3.5/s, respectively. Rates between 3.5 and 25/s undergo a gradual morphology transition, above which oscillations begin to occur after 100 ms. Conclusions: Auditory brainstem, middle and late latency components other than P2 show stable latencies across 0.3-40/s with varying amplitude rate dependencies. Significance: Obtaining a transient response rate profile utilizing uniform acquisition parameters is useful for an improved understanding of how individual AEP components interact with stimulation rate, and can provide a more comprehensive assessment of the ascending auditory pathway and primary auditory cortices.

AB - Objective: Auditory evoked potentials (AEPs) are typically acquired in either transient (low-rate) or steady state (high-rate) conditions. This study utilizes deconvolution to obtain transient responses over a range of rates from 0.3 to 40/s, to establish a rate profile of transient responses employing uniform recording conditions. Methods: Deconvolution is used to obtain transient responses from quasi steady state recordings for rates 3.5-40/s, and components are scored and waveform morphologies are compared across rates. Results: All component latencies remain stable across all rates other than P2, which decreases for rates up to 3.5/s. Amplitudes for brainstem (V, Na), middle latency (Pa, Nb), and late (Pb/P1, N1 and P2) responses increased for rates below 1, 2 and 3.5/s, respectively. Rates between 3.5 and 25/s undergo a gradual morphology transition, above which oscillations begin to occur after 100 ms. Conclusions: Auditory brainstem, middle and late latency components other than P2 show stable latencies across 0.3-40/s with varying amplitude rate dependencies. Significance: Obtaining a transient response rate profile utilizing uniform acquisition parameters is useful for an improved understanding of how individual AEP components interact with stimulation rate, and can provide a more comprehensive assessment of the ascending auditory pathway and primary auditory cortices.

KW - Adaptation

KW - Auditory evoked potentials

KW - Chirp

KW - Deconvolution

KW - Rate effects

KW - Transient response

UR - http://www.scopus.com/inward/record.url?scp=84958012637&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958012637&partnerID=8YFLogxK

U2 - 10.1016/j.clinph.2015.10.046

DO - 10.1016/j.clinph.2015.10.046

M3 - Article

C2 - 26639172

AN - SCOPUS:84958012637

VL - 127

SP - 1589

EP - 1602

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 2

ER -