Abstract
Objective: Auditory evoked potentials (AEPs) are typically acquired in either transient (low-rate) or steady state (high-rate) conditions. This study utilizes deconvolution to obtain transient responses over a range of rates from 0.3 to 40/s, to establish a rate profile of transient responses employing uniform recording conditions. Methods: Deconvolution is used to obtain transient responses from quasi steady state recordings for rates 3.5-40/s, and components are scored and waveform morphologies are compared across rates. Results: All component latencies remain stable across all rates other than P2, which decreases for rates up to 3.5/s. Amplitudes for brainstem (V, Na), middle latency (Pa, Nb), and late (Pb/P1, N1 and P2) responses increased for rates below 1, 2 and 3.5/s, respectively. Rates between 3.5 and 25/s undergo a gradual morphology transition, above which oscillations begin to occur after 100 ms. Conclusions: Auditory brainstem, middle and late latency components other than P2 show stable latencies across 0.3-40/s with varying amplitude rate dependencies. Significance: Obtaining a transient response rate profile utilizing uniform acquisition parameters is useful for an improved understanding of how individual AEP components interact with stimulation rate, and can provide a more comprehensive assessment of the ascending auditory pathway and primary auditory cortices.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1589-1602 |
| Number of pages | 14 |
| Journal | Clinical Neurophysiology |
| Volume | 127 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2016 |
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Keywords
- Adaptation
- Auditory evoked potentials
- Chirp
- Deconvolution
- Rate effects
- Transient response
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
- Physiology (medical)
- Sensory Systems
Cite this
Effects of rate (0.3-40/s) on simultaneously recorded auditory brainstem, middle and late responses using deconvolution. / Holt, Fred; Ozdamar, Ozcan.
In: Clinical Neurophysiology, Vol. 127, No. 2, 01.02.2016, p. 1589-1602.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of rate (0.3-40/s) on simultaneously recorded auditory brainstem, middle and late responses using deconvolution
AU - Holt, Fred
AU - Ozdamar, Ozcan
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Objective: Auditory evoked potentials (AEPs) are typically acquired in either transient (low-rate) or steady state (high-rate) conditions. This study utilizes deconvolution to obtain transient responses over a range of rates from 0.3 to 40/s, to establish a rate profile of transient responses employing uniform recording conditions. Methods: Deconvolution is used to obtain transient responses from quasi steady state recordings for rates 3.5-40/s, and components are scored and waveform morphologies are compared across rates. Results: All component latencies remain stable across all rates other than P2, which decreases for rates up to 3.5/s. Amplitudes for brainstem (V, Na), middle latency (Pa, Nb), and late (Pb/P1, N1 and P2) responses increased for rates below 1, 2 and 3.5/s, respectively. Rates between 3.5 and 25/s undergo a gradual morphology transition, above which oscillations begin to occur after 100 ms. Conclusions: Auditory brainstem, middle and late latency components other than P2 show stable latencies across 0.3-40/s with varying amplitude rate dependencies. Significance: Obtaining a transient response rate profile utilizing uniform acquisition parameters is useful for an improved understanding of how individual AEP components interact with stimulation rate, and can provide a more comprehensive assessment of the ascending auditory pathway and primary auditory cortices.
AB - Objective: Auditory evoked potentials (AEPs) are typically acquired in either transient (low-rate) or steady state (high-rate) conditions. This study utilizes deconvolution to obtain transient responses over a range of rates from 0.3 to 40/s, to establish a rate profile of transient responses employing uniform recording conditions. Methods: Deconvolution is used to obtain transient responses from quasi steady state recordings for rates 3.5-40/s, and components are scored and waveform morphologies are compared across rates. Results: All component latencies remain stable across all rates other than P2, which decreases for rates up to 3.5/s. Amplitudes for brainstem (V, Na), middle latency (Pa, Nb), and late (Pb/P1, N1 and P2) responses increased for rates below 1, 2 and 3.5/s, respectively. Rates between 3.5 and 25/s undergo a gradual morphology transition, above which oscillations begin to occur after 100 ms. Conclusions: Auditory brainstem, middle and late latency components other than P2 show stable latencies across 0.3-40/s with varying amplitude rate dependencies. Significance: Obtaining a transient response rate profile utilizing uniform acquisition parameters is useful for an improved understanding of how individual AEP components interact with stimulation rate, and can provide a more comprehensive assessment of the ascending auditory pathway and primary auditory cortices.
KW - Adaptation
KW - Auditory evoked potentials
KW - Chirp
KW - Deconvolution
KW - Rate effects
KW - Transient response
UR - http://www.scopus.com/inward/record.url?scp=84958012637&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84958012637&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2015.10.046
DO - 10.1016/j.clinph.2015.10.046
M3 - Article
C2 - 26639172
AN - SCOPUS:84958012637
VL - 127
SP - 1589
EP - 1602
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 2
ER -