Abstract
Psychological stress can have bidirectional effects on immune function, being immunosuppressive under certain conditions but immunoenhancing under others. Chronic stress (lasting for weeks, months, or years) is known to suppress or dysregulate immune function. Acute stress (lasting for minutes to hours) has been shown to enhance immune function, particularly in the skin. Acute stress experienced at the time of immune activation or antigen exposure significantly enhances primary/innate or secondary/adaptive immune responses. Acute stress induces a redistribution of leukocytes from the blood to compartments like the skin and sentinel lymph nodes, and this redistribution is thought to be one important mediator of the immunoenhancing effects of acute stress. The studies described here may provide substrates for interventions that could be designed to ameliorate stress-induced exacerbation of allergic, inflammatory, or auto-immune diseases. These studies also provide the framework for developing therapeutic interventions that may harness the body's endogenous adjuvant-like immunoenhancing mechanisms to enhance protective immunity during vaccination, infection, or wound healing.
| Original language | English (US) |
|---|---|
| Title of host publication | Neuroimmunology of the Skin |
| Subtitle of host publication | Basic Science to Clinical Practice |
| Publisher | Springer Berlin Heidelberg |
| Pages | 113-123 |
| Number of pages | 11 |
| ISBN (Print) | 9783540359869 |
| DOIs | |
| State | Published - Dec 1 2009 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Effects of psychological stress on skin immune function : Implications for immunoprotection versus immunopathology. / Dhabhar, Firdaus.
Neuroimmunology of the Skin: Basic Science to Clinical Practice. Springer Berlin Heidelberg, 2009. p. 113-123.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Effects of psychological stress on skin immune function
T2 - Implications for immunoprotection versus immunopathology
AU - Dhabhar, Firdaus
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Psychological stress can have bidirectional effects on immune function, being immunosuppressive under certain conditions but immunoenhancing under others. Chronic stress (lasting for weeks, months, or years) is known to suppress or dysregulate immune function. Acute stress (lasting for minutes to hours) has been shown to enhance immune function, particularly in the skin. Acute stress experienced at the time of immune activation or antigen exposure significantly enhances primary/innate or secondary/adaptive immune responses. Acute stress induces a redistribution of leukocytes from the blood to compartments like the skin and sentinel lymph nodes, and this redistribution is thought to be one important mediator of the immunoenhancing effects of acute stress. The studies described here may provide substrates for interventions that could be designed to ameliorate stress-induced exacerbation of allergic, inflammatory, or auto-immune diseases. These studies also provide the framework for developing therapeutic interventions that may harness the body's endogenous adjuvant-like immunoenhancing mechanisms to enhance protective immunity during vaccination, infection, or wound healing.
AB - Psychological stress can have bidirectional effects on immune function, being immunosuppressive under certain conditions but immunoenhancing under others. Chronic stress (lasting for weeks, months, or years) is known to suppress or dysregulate immune function. Acute stress (lasting for minutes to hours) has been shown to enhance immune function, particularly in the skin. Acute stress experienced at the time of immune activation or antigen exposure significantly enhances primary/innate or secondary/adaptive immune responses. Acute stress induces a redistribution of leukocytes from the blood to compartments like the skin and sentinel lymph nodes, and this redistribution is thought to be one important mediator of the immunoenhancing effects of acute stress. The studies described here may provide substrates for interventions that could be designed to ameliorate stress-induced exacerbation of allergic, inflammatory, or auto-immune diseases. These studies also provide the framework for developing therapeutic interventions that may harness the body's endogenous adjuvant-like immunoenhancing mechanisms to enhance protective immunity during vaccination, infection, or wound healing.
UR - http://www.scopus.com/inward/record.url?scp=84892050508&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892050508&partnerID=8YFLogxK
U2 - 10.1007/978-3-540-35989-0_11
DO - 10.1007/978-3-540-35989-0_11
M3 - Chapter
SN - 9783540359869
SP - 113
EP - 123
BT - Neuroimmunology of the Skin
PB - Springer Berlin Heidelberg
ER -