Abstract
The effects of the hypothalamic 28 aminoacid peptide prosomatostatin (Pro-SS) on arginine-induced growth hormone (GH) and prolactin (PRL) release and blood glucose levels in man are compared with those obtained after an equimolar dose of somatostatin (SS). In comparison with SS, Pro-SS caused greater and more prolonged inhibition of GH release, a more marked reduction of the PRL response to arginine, and greater enhancement of the hyperglycaemic action of arginine. The greater potency and prolonged action of Pro-SS make it an interesting tool to study hormonal control mechanisms in a variety of physiological and pathological conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 353-356 |
| Number of pages | 4 |
| Journal | The Lancet |
| Volume | 317 |
| Issue number | 8216 |
| DOIs | |
| State | Published - Feb 14 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
EFFECTS OF PROSOMATOSTATIN ON GROWTH HORMONE AND PROLACTIN RESPONSE TO ARGININE IN MAN Comparison with Somatostatin. / Rodriguez-Arnao, M. D.; Rainbow, S. J.; Comaru-Schally, A. M.; Meyers, C. A.; Gomez-Pan, A.; Woodhead, S.; Schally, Andrew V; Coy, D. H.; Hall, R.
In: The Lancet, Vol. 317, No. 8216, 14.02.1981, p. 353-356.Research output: Contribution to journal › Article
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TY - JOUR
T1 - EFFECTS OF PROSOMATOSTATIN ON GROWTH HORMONE AND PROLACTIN RESPONSE TO ARGININE IN MAN Comparison with Somatostatin
AU - Rodriguez-Arnao, M. D.
AU - Rainbow, S. J.
AU - Comaru-Schally, A. M.
AU - Meyers, C. A.
AU - Gomez-Pan, A.
AU - Woodhead, S.
AU - Schally, Andrew V
AU - Coy, D. H.
AU - Hall, R.
PY - 1981/2/14
Y1 - 1981/2/14
N2 - The effects of the hypothalamic 28 aminoacid peptide prosomatostatin (Pro-SS) on arginine-induced growth hormone (GH) and prolactin (PRL) release and blood glucose levels in man are compared with those obtained after an equimolar dose of somatostatin (SS). In comparison with SS, Pro-SS caused greater and more prolonged inhibition of GH release, a more marked reduction of the PRL response to arginine, and greater enhancement of the hyperglycaemic action of arginine. The greater potency and prolonged action of Pro-SS make it an interesting tool to study hormonal control mechanisms in a variety of physiological and pathological conditions.
AB - The effects of the hypothalamic 28 aminoacid peptide prosomatostatin (Pro-SS) on arginine-induced growth hormone (GH) and prolactin (PRL) release and blood glucose levels in man are compared with those obtained after an equimolar dose of somatostatin (SS). In comparison with SS, Pro-SS caused greater and more prolonged inhibition of GH release, a more marked reduction of the PRL response to arginine, and greater enhancement of the hyperglycaemic action of arginine. The greater potency and prolonged action of Pro-SS make it an interesting tool to study hormonal control mechanisms in a variety of physiological and pathological conditions.
UR - http://www.scopus.com/inward/record.url?scp=0019379323&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019379323&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(81)91673-1
DO - 10.1016/S0140-6736(81)91673-1
M3 - Article
VL - 317
SP - 353
EP - 356
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 8216
ER -