EFFECTS OF PROSOMATOSTATIN ON GROWTH HORMONE AND PROLACTIN RESPONSE TO ARGININE IN MAN Comparison with Somatostatin

M. D. Rodriguez-Arnao; S. J. Rainbow; A. M. Comaru-Schally; C. A. Meyers; A. Gomez-Pan; S. Woodhead; A. V. Schally; D. H. Coy; R. Hall

doi:10.1016/S0140-6736(81)91673-1

EFFECTS OF PROSOMATOSTATIN ON GROWTH HORMONE AND PROLACTIN RESPONSE TO ARGININE IN MAN Comparison with Somatostatin

M. D. Rodriguez-Arnao, S. J. Rainbow, A. M. Comaru-Schally, C. A. Meyers, A. Gomez-Pan, S. Woodhead, A. V. Schally, D. H. Coy, R. Hall

Pathology

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The effects of the hypothalamic 28 aminoacid peptide prosomatostatin (Pro-SS) on arginine-induced growth hormone (GH) and prolactin (PRL) release and blood glucose levels in man are compared with those obtained after an equimolar dose of somatostatin (SS). In comparison with SS, Pro-SS caused greater and more prolonged inhibition of GH release, a more marked reduction of the PRL response to arginine, and greater enhancement of the hyperglycaemic action of arginine. The greater potency and prolonged action of Pro-SS make it an interesting tool to study hormonal control mechanisms in a variety of physiological and pathological conditions.

Original language	English (US)
Pages (from-to)	353-356
Number of pages	4
Journal	The Lancet
Volume	317
Issue number	8216
DOIs	https://doi.org/10.1016/S0140-6736(81)91673-1
State	Published - Feb 14 1981

ASJC Scopus subject areas

Medicine(all)

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EFFECTS OF PROSOMATOSTATIN ON GROWTH HORMONE AND PROLACTIN RESPONSE TO ARGININE IN MAN Comparison with Somatostatin. / Rodriguez-Arnao, M. D.; Rainbow, S. J.; Comaru-Schally, A. M.; Meyers, C. A.; Gomez-Pan, A.; Woodhead, S.; Schally, A. V.; Coy, D. H.; Hall, R.

In: The Lancet, Vol. 317, No. 8216, 14.02.1981, p. 353-356.

Research output: Contribution to journal › Article › peer-review

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abstract = "The effects of the hypothalamic 28 aminoacid peptide prosomatostatin (Pro-SS) on arginine-induced growth hormone (GH) and prolactin (PRL) release and blood glucose levels in man are compared with those obtained after an equimolar dose of somatostatin (SS). In comparison with SS, Pro-SS caused greater and more prolonged inhibition of GH release, a more marked reduction of the PRL response to arginine, and greater enhancement of the hyperglycaemic action of arginine. The greater potency and prolonged action of Pro-SS make it an interesting tool to study hormonal control mechanisms in a variety of physiological and pathological conditions.",

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