Effects of platelet inhibitors on the platelet aggregation induced by plasma from patients with thrombotic thrombocytopenic purpura

E. C Y Lian, Niramol Savaraj

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Antiplatelet drugs have been used in the treatment of thrombotic thrombocytopenic purpura (TTP) but their in vivo efficacy remains controversial. It has been shown that, in vitro, the plasmas obtained from patients with TTP induced the aggregation of washed platelets from normal donors as well as patients in remission. The effects of platelet inhibitors on the TTP plasma-induced platelet aggregation were examined. It was found that aspirin, indomethacin, ibuprofen, sulfinpyrazone, 5, 8, 11, 14-eisacotetraynoic acid, prostaglandin E1, prostaglandin I2, dBcAMP, apyrase, creatine phosphate/creatine phosphokinase, antimycin, 2-deoxy-D-glucose, dipyridamole, clofibrate, dextran 40, dextran 70, dibucaine, xylocaine, methylmaleimide, and ethylenediamine tetraacetic acid had little or no effect at all. These data lead us to conclude that at least in certain cases, antiplatelet drugs probably play a limited role in the treatment of patients with TTP.

Original languageEnglish
Pages (from-to)354-359
Number of pages6
JournalBlood
Volume58
Issue number2
StatePublished - Dec 1 1981
Externally publishedYes

Fingerprint

Thrombotic Thrombocytopenic Purpura
Platelet Aggregation Inhibitors
Platelets
Platelet Aggregation
ethylenediamine
Agglomeration
Dextrans
Plasmas
Sulfinpyrazone
Dibucaine
Apyrase
Clofibrate
Acids
Phosphocreatine
Dipyridamole
Alprostadil
Ibuprofen
Deoxyglucose
Epoprostenol
Creatine Kinase

ASJC Scopus subject areas

  • Hematology

Cite this

Effects of platelet inhibitors on the platelet aggregation induced by plasma from patients with thrombotic thrombocytopenic purpura. / Lian, E. C Y; Savaraj, Niramol.

In: Blood, Vol. 58, No. 2, 01.12.1981, p. 354-359.

Research output: Contribution to journalArticle

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