Effects of physiologic human brain motion on proton spectroscopy

Quantitative analysis and correction with cardiac gating

Pradip Pattany, Imad H. Khamis, Brian C. Bowen, Karl Goodkin, R. Gregory Weaver, James B. Murdoch, M. Judith Post, Robert Quencer

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Proton MR spectroscopy is a powerful noninvasive method that enables measurement of certain brain metabolites in healthy subjects and patients with diseases. A major difficulty with clinical and research applications of in vivo proton MR spectroscopy is the variability of metabolite concentrations, especially in regions with substantial physiologic motion. In our preliminary evaluation, we tested the hypothesis that physiologic brain motion leads to lower mean metabolite concentrations and higher SDs for the measured metabolite concentrations.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume23
Issue number2
StatePublished - Mar 2 2002

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Protons
Spectrum Analysis
Magnetic Resonance Spectroscopy
Brain
Healthy Volunteers
Research

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Effects of physiologic human brain motion on proton spectroscopy : Quantitative analysis and correction with cardiac gating. / Pattany, Pradip; Khamis, Imad H.; Bowen, Brian C.; Goodkin, Karl; Weaver, R. Gregory; Murdoch, James B.; Judith Post, M.; Quencer, Robert.

In: American Journal of Neuroradiology, Vol. 23, No. 2, 02.03.2002, p. 225-230.

Research output: Contribution to journalArticle

Pattany, Pradip ; Khamis, Imad H. ; Bowen, Brian C. ; Goodkin, Karl ; Weaver, R. Gregory ; Murdoch, James B. ; Judith Post, M. ; Quencer, Robert. / Effects of physiologic human brain motion on proton spectroscopy : Quantitative analysis and correction with cardiac gating. In: American Journal of Neuroradiology. 2002 ; Vol. 23, No. 2. pp. 225-230.
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