Effects of phosphatidylcholine administration to rats on choline in blood and choline and acetylcholine in brain

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Phosphatidylcholine (PCh) administered intragastrically to rats resulted in a prolonged increase of the choline (Ch) concentration in plasma and erythrocytes. Plasma Ch was increased between 1 and 24 hr after administration of 10 mmol of PCh/kg with a peak level (256% of control) occurring 6 hr after treatment. The concentration of Ch in the striatum, hippocampus and cortex was increased after PCh treatment but the acetylcholine (ACh) concentrations did not change. PCh pretreatment antagonized the depletion of ACh caused by treatment with atropine, pentylenetetrazole or fluphenazine. Oxotremorine antagonized the effect of atropine but not of pentylenetetrazole or fluphenazine. Therefore, Ch derived from PCh supports ACh synthesis under conditions in which ACh release is stimulated, whereas under normal conditions the concentration of ACh is maintained within a relatively narrow range irrespective of the Ch concentration.

Original languageEnglish
Pages (from-to)322-328
Number of pages7
JournalJournal of Pharmacology and Experimental Therapeutics
Volume220
Issue number2
StatePublished - Jan 1 1982
Externally publishedYes

Fingerprint

Choline
Phosphatidylcholines
Acetylcholine
Brain
Fluphenazine
Pentylenetetrazole
Atropine
Oxotremorine
Hippocampus
Erythrocytes

ASJC Scopus subject areas

  • Pharmacology

Cite this

@article{f5763e6221e84914b26b076da6ce88cd,
title = "Effects of phosphatidylcholine administration to rats on choline in blood and choline and acetylcholine in brain",
abstract = "Phosphatidylcholine (PCh) administered intragastrically to rats resulted in a prolonged increase of the choline (Ch) concentration in plasma and erythrocytes. Plasma Ch was increased between 1 and 24 hr after administration of 10 mmol of PCh/kg with a peak level (256{\%} of control) occurring 6 hr after treatment. The concentration of Ch in the striatum, hippocampus and cortex was increased after PCh treatment but the acetylcholine (ACh) concentrations did not change. PCh pretreatment antagonized the depletion of ACh caused by treatment with atropine, pentylenetetrazole or fluphenazine. Oxotremorine antagonized the effect of atropine but not of pentylenetetrazole or fluphenazine. Therefore, Ch derived from PCh supports ACh synthesis under conditions in which ACh release is stimulated, whereas under normal conditions the concentration of ACh is maintained within a relatively narrow range irrespective of the Ch concentration.",
author = "Jope, {Richard S}",
year = "1982",
month = "1",
day = "1",
language = "English",
volume = "220",
pages = "322--328",
journal = "Journal of Pharmacology and Experimental Therapeutics",
issn = "0022-3565",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
number = "2",

}

TY - JOUR

T1 - Effects of phosphatidylcholine administration to rats on choline in blood and choline and acetylcholine in brain

AU - Jope, Richard S

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Phosphatidylcholine (PCh) administered intragastrically to rats resulted in a prolonged increase of the choline (Ch) concentration in plasma and erythrocytes. Plasma Ch was increased between 1 and 24 hr after administration of 10 mmol of PCh/kg with a peak level (256% of control) occurring 6 hr after treatment. The concentration of Ch in the striatum, hippocampus and cortex was increased after PCh treatment but the acetylcholine (ACh) concentrations did not change. PCh pretreatment antagonized the depletion of ACh caused by treatment with atropine, pentylenetetrazole or fluphenazine. Oxotremorine antagonized the effect of atropine but not of pentylenetetrazole or fluphenazine. Therefore, Ch derived from PCh supports ACh synthesis under conditions in which ACh release is stimulated, whereas under normal conditions the concentration of ACh is maintained within a relatively narrow range irrespective of the Ch concentration.

AB - Phosphatidylcholine (PCh) administered intragastrically to rats resulted in a prolonged increase of the choline (Ch) concentration in plasma and erythrocytes. Plasma Ch was increased between 1 and 24 hr after administration of 10 mmol of PCh/kg with a peak level (256% of control) occurring 6 hr after treatment. The concentration of Ch in the striatum, hippocampus and cortex was increased after PCh treatment but the acetylcholine (ACh) concentrations did not change. PCh pretreatment antagonized the depletion of ACh caused by treatment with atropine, pentylenetetrazole or fluphenazine. Oxotremorine antagonized the effect of atropine but not of pentylenetetrazole or fluphenazine. Therefore, Ch derived from PCh supports ACh synthesis under conditions in which ACh release is stimulated, whereas under normal conditions the concentration of ACh is maintained within a relatively narrow range irrespective of the Ch concentration.

UR - http://www.scopus.com/inward/record.url?scp=0020026833&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020026833&partnerID=8YFLogxK

M3 - Article

C2 - 7057393

AN - SCOPUS:0020026833

VL - 220

SP - 322

EP - 328

JO - Journal of Pharmacology and Experimental Therapeutics

JF - Journal of Pharmacology and Experimental Therapeutics

SN - 0022-3565

IS - 2

ER -