Abstract
Phosphatidylcholine (PCh) administered intragastrically to rats resulted in a prolonged increase of the choline (Ch) concentration in plasma and erythrocytes. Plasma Ch was increased between 1 and 24 hr after administration of 10 mmol of PCh/kg with a peak level (256% of control) occurring 6 hr after treatment. The concentration of Ch in the striatum, hippocampus and cortex was increased after PCh treatment but the acetylcholine (ACh) concentrations did not change. PCh pretreatment antagonized the depletion of ACh caused by treatment with atropine, pentylenetetrazole or fluphenazine. Oxotremorine antagonized the effect of atropine but not of pentylenetetrazole or fluphenazine. Therefore, Ch derived from PCh supports ACh synthesis under conditions in which ACh release is stimulated, whereas under normal conditions the concentration of ACh is maintained within a relatively narrow range irrespective of the Ch concentration.
| Original language | English |
|---|---|
| Pages (from-to) | 322-328 |
| Number of pages | 7 |
| Journal | Journal of Pharmacology and Experimental Therapeutics |
| Volume | 220 |
| Issue number | 2 |
| State | Published - Jan 1 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Effects of phosphatidylcholine administration to rats on choline in blood and choline and acetylcholine in brain. / Jope, Richard S.
In: Journal of Pharmacology and Experimental Therapeutics, Vol. 220, No. 2, 01.01.1982, p. 322-328.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Effects of phosphatidylcholine administration to rats on choline in blood and choline and acetylcholine in brain
AU - Jope, Richard S
PY - 1982/1/1
Y1 - 1982/1/1
N2 - Phosphatidylcholine (PCh) administered intragastrically to rats resulted in a prolonged increase of the choline (Ch) concentration in plasma and erythrocytes. Plasma Ch was increased between 1 and 24 hr after administration of 10 mmol of PCh/kg with a peak level (256% of control) occurring 6 hr after treatment. The concentration of Ch in the striatum, hippocampus and cortex was increased after PCh treatment but the acetylcholine (ACh) concentrations did not change. PCh pretreatment antagonized the depletion of ACh caused by treatment with atropine, pentylenetetrazole or fluphenazine. Oxotremorine antagonized the effect of atropine but not of pentylenetetrazole or fluphenazine. Therefore, Ch derived from PCh supports ACh synthesis under conditions in which ACh release is stimulated, whereas under normal conditions the concentration of ACh is maintained within a relatively narrow range irrespective of the Ch concentration.
AB - Phosphatidylcholine (PCh) administered intragastrically to rats resulted in a prolonged increase of the choline (Ch) concentration in plasma and erythrocytes. Plasma Ch was increased between 1 and 24 hr after administration of 10 mmol of PCh/kg with a peak level (256% of control) occurring 6 hr after treatment. The concentration of Ch in the striatum, hippocampus and cortex was increased after PCh treatment but the acetylcholine (ACh) concentrations did not change. PCh pretreatment antagonized the depletion of ACh caused by treatment with atropine, pentylenetetrazole or fluphenazine. Oxotremorine antagonized the effect of atropine but not of pentylenetetrazole or fluphenazine. Therefore, Ch derived from PCh supports ACh synthesis under conditions in which ACh release is stimulated, whereas under normal conditions the concentration of ACh is maintained within a relatively narrow range irrespective of the Ch concentration.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020026833&partnerID=8YFLogxK
M3 - Article
C2 - 7057393
AN - SCOPUS:0020026833
VL - 220
SP - 322
EP - 328
JO - Journal of Pharmacology and Experimental Therapeutics
JF - Journal of Pharmacology and Experimental Therapeutics
SN - 0022-3565
IS - 2
ER -