Effects of nitric acid on carbachol reactivity of the airways in normal and allergic sheep

W. M. Abraham, C. S. Kim, M. M. King, W. Oliver, L. Yerger

Research output: Contribution to journalArticle

10 Scopus citations


The airway effects of a 4-hr exposure (via a Plexiglas hood) to 1.6 ppm nitric acid vapor were evaluated in seven normal and seven allergic sheep, i.e., animals that have a history of reacting with bronchospasm to inhalation challenge with Ascaris suum antigen. The nitric acid vapor was generated by ultrasonic nebulization of a 2% nitric acid solution. Airway effects were assessed by measuring the change in specific pulmonary flow resistance before and after a standard inhalation challenge with 2.5% carbachoi aerosol. Nitric acid exposure did not produce bronchoconstriction in either group. Pre-exposure increases in specific pulmonary flow resistance after carbachoi Inhalation were 68% (SD ± 13%) and 82% (SD ± 35%) for the normal and allergic sheep, respectively, Within 24 hr, the largest postexposure increases in specific pulmonary flow resistance for the normal and allergic sheep were 108% [SD ± 51% (P

Original languageEnglish (US)
Pages (from-to)153-159
Number of pages7
JournalArchives of Environmental Health
Issue number1
StatePublished - 1982
Externally publishedYes


ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis

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