Effects of nitric acid on carbachol reactivity of the airways in normal and allergic sheep

W. M. Abraham, C. S. Kim, M. M. King, W. Oliver, L. Yerger

Research output: Contribution to journalArticle

Abstract

The airway effects of a 4-hr exposure (via a Plexiglas hood) to 1.6 ppm nitric acid vapor were evaluated in seven normal and seven allergic sheep, i.e., animals that have a history of reacting with bronchospasm to inhalation challenge with Ascaris suum antigen. The nitric acid vapor was generated by ultrasonic nebulization of a 2% nitric acid solution. Airway effects were assessed by measuring the change in specific pulmonary flow resistance before and after a standard inhalation challenge with 2.5% carbachol aerosol. Nitric acid exposure did not produce bronchoconstriction in either group. Pre-exposure increases in specific pulmonary flow resistance after carbachol inhalation were 68% (SD ± 13%) and 82% (SD ± 35%) for the normal and allergic sheep, respectively. Within 24 hr, the largest postexposure increases in specific pulmonary flow resistance for the normal and allergic sheep were 108% [SD ± 51% (P < .06)] and 175% [SD ± 87% (P < .02)], respectively. We conclude that a short-term exposure to nitric acid vapor at levels below the industrial threshold limit (2 ppm), produces airway hyperreactivity to aerosolized carbachol in allergic sheep.

Original languageEnglish
Pages (from-to)36-40
Number of pages5
JournalArchives of Environmental Health
Volume37
Issue number1
StatePublished - May 28 1982
Externally publishedYes

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

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  • Cite this

    Abraham, W. M., Kim, C. S., King, M. M., Oliver, W., & Yerger, L. (1982). Effects of nitric acid on carbachol reactivity of the airways in normal and allergic sheep. Archives of Environmental Health, 37(1), 36-40.