Effects of neurotrophins on early auditory neurones in cell culture

Brigitte Malgrange, Philippe Lefebvre, Thomas R Van De Water, Hinrich Staecker, Gustave Moonen

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

DURING the first week of postnatal development, the innervation of the organ of Corti changes from an immature to an adult pattern. Dissociated cell cultures of early postnatal spiral ganglia were used to investigate the effects of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) on maturing auditory neurones. BDNF was the most potent stimulator of neuritogenesis, NT-3 provided the strongest support for neuronal survival, while NGF supported limited neuritogenesis, and only at pharmacological levels. These findings suggest that both BDNF and NT-3 participate in the postnatal maturation of cochlear innervation and that NGF is most probably not involved in this process.

Original languageEnglish
Pages (from-to)913-917
Number of pages5
JournalNeuroReport
Volume7
Issue number4
StatePublished - Jun 10 1996
Externally publishedYes

Fingerprint

Neurotrophin 3
Brain-Derived Neurotrophic Factor
Nerve Growth Factors
Nerve Growth Factor
Cell Culture Techniques
Neurons
Spiral Ganglion
Organ of Corti
Cochlea
Pharmacology

Keywords

  • Auditory neurones
  • Innervation
  • Maturation
  • Neurotrophins
  • Organ of Corti
  • Postnatal
  • Trophic effects

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Malgrange, B., Lefebvre, P., Van De Water, T. R., Staecker, H., & Moonen, G. (1996). Effects of neurotrophins on early auditory neurones in cell culture. NeuroReport, 7(4), 913-917.

Effects of neurotrophins on early auditory neurones in cell culture. / Malgrange, Brigitte; Lefebvre, Philippe; Van De Water, Thomas R; Staecker, Hinrich; Moonen, Gustave.

In: NeuroReport, Vol. 7, No. 4, 10.06.1996, p. 913-917.

Research output: Contribution to journalArticle

Malgrange, B, Lefebvre, P, Van De Water, TR, Staecker, H & Moonen, G 1996, 'Effects of neurotrophins on early auditory neurones in cell culture', NeuroReport, vol. 7, no. 4, pp. 913-917.
Malgrange B, Lefebvre P, Van De Water TR, Staecker H, Moonen G. Effects of neurotrophins on early auditory neurones in cell culture. NeuroReport. 1996 Jun 10;7(4):913-917.
Malgrange, Brigitte ; Lefebvre, Philippe ; Van De Water, Thomas R ; Staecker, Hinrich ; Moonen, Gustave. / Effects of neurotrophins on early auditory neurones in cell culture. In: NeuroReport. 1996 ; Vol. 7, No. 4. pp. 913-917.
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