Effects of neuraminidase on the regulation erythropoiesis

V. F. LaRussa, F. Sieber, L. L. Sensenbrenner, S. J. Sharkis

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this article, we present evidence that sialic acid-containing surface components play a role in the regulation of erythropoiesis. A 1-hr exposure of mouse bone marrow cells to high concentrations of neuroaminidase reduced erythroid colony formation. Coculture of 106 untreated thymocytes with neuraminidase-treated bone marrow cells restored erythroid colony growth. Neuraminidase-treated thymocytes retained their ability to suppress erythroid colony formation by untreated marrow cells, but lost their ability to enhance erythroid colony formation. Continuous exposure to low concentrations of neuroaminidase enhanced erythroid bone marrow cell colony growth in response to a suboptimal dose of erythropoietin.

Original languageEnglish
Pages (from-to)784-788
Number of pages5
JournalBlood
Volume63
Issue number4
StatePublished - Jun 28 1984

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Erythropoiesis
Neuraminidase
Bone Marrow Cells
Cells
Thymocytes
Bone
Hairless Mouse
Erythroid Cells
N-Acetylneuraminic Acid
Growth
Erythropoietin
Coculture Techniques
Bone Marrow

ASJC Scopus subject areas

  • Hematology

Cite this

LaRussa, V. F., Sieber, F., Sensenbrenner, L. L., & Sharkis, S. J. (1984). Effects of neuraminidase on the regulation erythropoiesis. Blood, 63(4), 784-788.

Effects of neuraminidase on the regulation erythropoiesis. / LaRussa, V. F.; Sieber, F.; Sensenbrenner, L. L.; Sharkis, S. J.

In: Blood, Vol. 63, No. 4, 28.06.1984, p. 784-788.

Research output: Contribution to journalArticle

LaRussa, VF, Sieber, F, Sensenbrenner, LL & Sharkis, SJ 1984, 'Effects of neuraminidase on the regulation erythropoiesis', Blood, vol. 63, no. 4, pp. 784-788.
LaRussa VF, Sieber F, Sensenbrenner LL, Sharkis SJ. Effects of neuraminidase on the regulation erythropoiesis. Blood. 1984 Jun 28;63(4):784-788.
LaRussa, V. F. ; Sieber, F. ; Sensenbrenner, L. L. ; Sharkis, S. J. / Effects of neuraminidase on the regulation erythropoiesis. In: Blood. 1984 ; Vol. 63, No. 4. pp. 784-788.
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