Effects of motor unit size on innervation patterns in neonatal mammals

John Bixby, John H R Maunsell, David C. Van Essen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Different muscles in neonatal rabbits differ with respect to the extent of multiple innervation and the rate of synapse elimination. Counts were made of both α-motor neurons (using retrograde transport of horseradish peroxidase) and muscle fibers for each of three rabbit muscles, to see whether the differences between muscles in the degree of multiple innervation and/or the rate of synapse elimination were related to the motor neuron:muscle fiber ratio (the innervation ratio). The results suggest that individual motor neurons from muscles with a 10-fold range of muscle fiber number tend initially to establish a similar number of synapses, which results in different degrees of multiple innervation among muscles. The rate of synapse elimination in a muscle, however, does not appear to depend on the innervation ratio.

Original languageEnglish
Pages (from-to)516-524
Number of pages9
JournalExperimental Neurology
Volume70
Issue number3
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

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Mammals
Muscles
Synapses
Motor Neurons
Rabbits
Horseradish Peroxidase

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Effects of motor unit size on innervation patterns in neonatal mammals. / Bixby, John; Maunsell, John H R; Van Essen, David C.

In: Experimental Neurology, Vol. 70, No. 3, 01.01.1980, p. 516-524.

Research output: Contribution to journalArticle

Bixby, John ; Maunsell, John H R ; Van Essen, David C. / Effects of motor unit size on innervation patterns in neonatal mammals. In: Experimental Neurology. 1980 ; Vol. 70, No. 3. pp. 516-524.
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