Effects of mechanical properties and proteolytic degradation on angiogenic process extension into L1Ig6-modified fibrin matrices in vitro

H. Hall, L. Urech, J. A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The mechanical properties of native fibrin matrices covalently modified with ligand L11g6 for angiogenic endothelial cells were analyzed. Native fibrin matrices showed increasing mechanical stability when produced with increasing concentrations of exogenous factor XIII. Human umbilical vein endothelial cells (HUVEC) extended processes into those matrices. Process extension depended on biological modifications with a ligand L11g6 for αvβ3-integrin as well as on the mechanical properties of the matrix. Results show that the HUVEC process extension into three-dimensional fibrin matrices depended on the mechanical properties, the availability of proper adhesion signals and proteolytic degradation on the matrix.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
StatePublished - Dec 1 2004
Externally publishedYes
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

Fingerprint

Endothelial cells
Degradation
Mechanical properties
Ligands
Mechanical stability
Adhesion
Availability

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Hall, H., Urech, L., & Hubbell, J. A. (2004). Effects of mechanical properties and proteolytic degradation on angiogenic process extension into L1Ig6-modified fibrin matrices in vitro. In Transactions - 7th World Biomaterials Congress

Effects of mechanical properties and proteolytic degradation on angiogenic process extension into L1Ig6-modified fibrin matrices in vitro. / Hall, H.; Urech, L.; Hubbell, J. A.

Transactions - 7th World Biomaterials Congress. 2004.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hall, H, Urech, L & Hubbell, JA 2004, Effects of mechanical properties and proteolytic degradation on angiogenic process extension into L1Ig6-modified fibrin matrices in vitro. in Transactions - 7th World Biomaterials Congress. Transactions - 7th World Biomaterials Congress, Sydney, Australia, 5/17/04.
Hall, H. ; Urech, L. ; Hubbell, J. A. / Effects of mechanical properties and proteolytic degradation on angiogenic process extension into L1Ig6-modified fibrin matrices in vitro. Transactions - 7th World Biomaterials Congress. 2004.
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