Effects of luteinizing hormone-releasing hormone analogue on DNA synthesis in rat prostate and uterus

S. Sakamoto, M. Tajima, K. Sawaki, S. Suzuki, H. Kudo, S. Sassa, K. Kuwa, Y. Sugiura, N. Kasahara, H. Nagasawa

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Buserelin, a potent LH-RH agonist, has been used for the treatment of hormonal disorders such as precocious puberty, endometriosis, cystic mastitis and prostatic carcinoma. Prolonged treatment with buserelin has been known to induce a refractory phase of pituitary desensitization. In the present study, we found that two-week treatment with buserelin strongly suppressed the activities of thymidylate synthetase and thymidine kinase, and markedly reduced the appearance of BrdU-immunoreactive (S-phase) cells in both prostate glands and uteri in male and female adult rats, respectively.

Original languageEnglish (US)
Pages (from-to)13-16
Number of pages4
JournalIn Vivo
Volume7
Issue number1
StatePublished - Jan 1 1993
Externally publishedYes

Keywords

  • BrdU
  • LH-RH
  • endometrium
  • prostate gland
  • thymidine kinase
  • thymidylate synthetase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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    Sakamoto, S., Tajima, M., Sawaki, K., Suzuki, S., Kudo, H., Sassa, S., Kuwa, K., Sugiura, Y., Kasahara, N., & Nagasawa, H. (1993). Effects of luteinizing hormone-releasing hormone analogue on DNA synthesis in rat prostate and uterus. In Vivo, 7(1), 13-16.