Effects of ketamine sedation on glucose clearance, insulin secretion and counterregulatory hormone production in baboons (Papio hamadryas)

R. Lehmann, J. L. Wagner, L. A. Fernandez, J. J. Bourgoignie, C. Ricordi, R. Alejandro, N. S. Kenyon

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Since the effects of ketamine sedation seem to differ between subspecies of baboons, we assessed the endocrine response to an intravenous glucose tolerance test (IVGTT) in 12 hamadryas baboons. The first phase insulin secretion, basal insulin, and glucose levels, as well as the glucose clearance, were significantly lower in sedated baboons as compared to fully awake animals. Glucagon and cortisol were significantly higher, while growth hormone was lower during ketamine sedation. Papio hamadryas appears to be a promising pre-clinical model for the study of endocrine replacement therapy in insulin-dependent diabetes. However, the data obtained must be interpreted with the knowledge that the anesthetic employed to allow for testing of the animals does have an effect on the parameters described in this report.

Original languageEnglish (US)
Pages (from-to)312-321
Number of pages10
JournalJournal of medical primatology
Volume26
Issue number6
DOIs
StatePublished - Jan 1 1997

Keywords

  • Diabetes
  • First phase insulin secretion
  • Glucagon cortisol
  • Growth hormone
  • IDDM
  • Insulin
  • IVGTT
  • Ketamine
  • Non-human primate

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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