Effects of intrahypothalamic injection of quinolinic acid on anterior pituitary hormone secretion in the unanesthetized rat

Charles Nemeroff, G. A. Mason, G. Bissette, D. A. Parks, R. Schwarcz

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Bilateral intrahypothalamic injections of the brain metabolite quinolinic acid (QUIN) were made in an attempt to examine its effects on the secretion of LH, PRL, GH and TSH. QUIN, a neuroexcitatory amino acid with close structural similarities to glutamate, kainate and N-methylaspartate, was infused into unanesthetized male rats, the animals sacrificed 7.5 min later, and serum hormone concentrations determined by radioimmunoassay. QUIN caused surges in LH, PRL and GH release (316, 607 and 1,134% of control, respectively, at 50 μg QUIN) without affecting the serum concentrations of TSH. At lower doses, a preferential effect of QUIN on PRL release was observed. All QUIN-induced hormonal changes were inhibited by concomitant administration of the specific antagonist (-)-2-amino-7-phosphonoheptanoic acid, indicating the presence of QUIN-sensitive receptors on neurons which are intimately associated with endocrine regulation. Moreover, because QUIN-treated animals exhibited behavioral signs of seizure activity and neuroendocrine dysfunction has been reported to occur in human convulsive disorders, the data are also of interest in view of a possible mechanistic link between epileptic phenomena and hormone secretion.

Original languageEnglish
Pages (from-to)332-336
Number of pages5
JournalNeuroendocrinology
Volume41
Issue number4
StatePublished - Nov 6 1985
Externally publishedYes

Fingerprint

Anterior Pituitary Hormones
Quinolinic Acid
Injections
2-amino-7-phosphonoheptanoic acid
Hormones
Kainic Acid
N-Methylaspartate
Serum
Radioimmunoassay
Glutamic Acid
Seizures
Neurons
Amino Acids

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

Effects of intrahypothalamic injection of quinolinic acid on anterior pituitary hormone secretion in the unanesthetized rat. / Nemeroff, Charles; Mason, G. A.; Bissette, G.; Parks, D. A.; Schwarcz, R.

In: Neuroendocrinology, Vol. 41, No. 4, 06.11.1985, p. 332-336.

Research output: Contribution to journalArticle

Nemeroff, Charles ; Mason, G. A. ; Bissette, G. ; Parks, D. A. ; Schwarcz, R. / Effects of intrahypothalamic injection of quinolinic acid on anterior pituitary hormone secretion in the unanesthetized rat. In: Neuroendocrinology. 1985 ; Vol. 41, No. 4. pp. 332-336.
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