Abstract
Background and hypothesis: Carbon dioxide is currently used as an arterial and venous contrast agent; however, little is known of its effects on left ventricular function. This study was undertaken to investigate those effects. Methods: Ascending doses of 5, 10, and 20 ml of carbon dioxide were administered into the left main coronary artery of domestic swine with and without a continuous infusion of intravenous nitroglycerin (50 μg/min). Results: Carbon dioxide had an immediate and profound depressant effect on both systolic and diastolic left ventricular function associated with ischemic electrocardiographic changes. Compared with controls (% change), ascending doses of carbon dioxide decreased systolic pressure by -35 ± 7, - 48 ± 8, and -53 ± 4 in the absence of nitroglycerin, and by -32 ± 9, -50 ± 9, and -60 ± 9 in the presence of nitroglycerin. Peak +dP/dt decreased by -54 ± 7, -61 ± 11, and -64 ± 3 in the absence of nitroglycerin, and by 36 ± 13, -55 ± 11, and -65 ± 11 in the presence of nitroglycerin. Minimum - dP/dt increased by 65 ± 8, 71 ± 8, and 77 ± 3 in the absence of nitroglycerin, and by 63 ± 7, 71 ± 8, and 78 ± 7 in the presence of nitroglycerin. No significant changes in heart rate were observed; however, widespread ST-segment elevation was observed in all animals. Coronary angiography following carbon dioxide injection revealed a marked decrease in coronary flow velocity until the gas was cleared from the microcirculation. This was also documented by direct measurement of flow velocity using a Doppler catheter in an additional animal. Left ventriculography demonstrated immediate global dilation and depression of systolic function. Conclusions: In the swine model, relatively small doses of intracoronary carbon dioxide cause profound yet reversible global left ventricular dysfunction which appears to be ischemic in origin.
| Original language | English |
|---|---|
| Pages (from-to) | 461-465 |
| Number of pages | 5 |
| Journal | Clinical Cardiology |
| Volume | 19 |
| Issue number | 6 |
| State | Published - Jun 1 1996 |
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Keywords
- arteriography
- contrast media
- coronary angiography
- ischemia
- left ventricular function
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Effects of intracoronary carbon dioxide on left ventricular function in swine. / Lambert, Charles R.; De Marchena, Eduardo; Bikkina, Mahesh; Arcement, Brian K.
In: Clinical Cardiology, Vol. 19, No. 6, 01.06.1996, p. 461-465.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of intracoronary carbon dioxide on left ventricular function in swine
AU - Lambert, Charles R.
AU - De Marchena, Eduardo
AU - Bikkina, Mahesh
AU - Arcement, Brian K.
PY - 1996/6/1
Y1 - 1996/6/1
N2 - Background and hypothesis: Carbon dioxide is currently used as an arterial and venous contrast agent; however, little is known of its effects on left ventricular function. This study was undertaken to investigate those effects. Methods: Ascending doses of 5, 10, and 20 ml of carbon dioxide were administered into the left main coronary artery of domestic swine with and without a continuous infusion of intravenous nitroglycerin (50 μg/min). Results: Carbon dioxide had an immediate and profound depressant effect on both systolic and diastolic left ventricular function associated with ischemic electrocardiographic changes. Compared with controls (% change), ascending doses of carbon dioxide decreased systolic pressure by -35 ± 7, - 48 ± 8, and -53 ± 4 in the absence of nitroglycerin, and by -32 ± 9, -50 ± 9, and -60 ± 9 in the presence of nitroglycerin. Peak +dP/dt decreased by -54 ± 7, -61 ± 11, and -64 ± 3 in the absence of nitroglycerin, and by 36 ± 13, -55 ± 11, and -65 ± 11 in the presence of nitroglycerin. Minimum - dP/dt increased by 65 ± 8, 71 ± 8, and 77 ± 3 in the absence of nitroglycerin, and by 63 ± 7, 71 ± 8, and 78 ± 7 in the presence of nitroglycerin. No significant changes in heart rate were observed; however, widespread ST-segment elevation was observed in all animals. Coronary angiography following carbon dioxide injection revealed a marked decrease in coronary flow velocity until the gas was cleared from the microcirculation. This was also documented by direct measurement of flow velocity using a Doppler catheter in an additional animal. Left ventriculography demonstrated immediate global dilation and depression of systolic function. Conclusions: In the swine model, relatively small doses of intracoronary carbon dioxide cause profound yet reversible global left ventricular dysfunction which appears to be ischemic in origin.
AB - Background and hypothesis: Carbon dioxide is currently used as an arterial and venous contrast agent; however, little is known of its effects on left ventricular function. This study was undertaken to investigate those effects. Methods: Ascending doses of 5, 10, and 20 ml of carbon dioxide were administered into the left main coronary artery of domestic swine with and without a continuous infusion of intravenous nitroglycerin (50 μg/min). Results: Carbon dioxide had an immediate and profound depressant effect on both systolic and diastolic left ventricular function associated with ischemic electrocardiographic changes. Compared with controls (% change), ascending doses of carbon dioxide decreased systolic pressure by -35 ± 7, - 48 ± 8, and -53 ± 4 in the absence of nitroglycerin, and by -32 ± 9, -50 ± 9, and -60 ± 9 in the presence of nitroglycerin. Peak +dP/dt decreased by -54 ± 7, -61 ± 11, and -64 ± 3 in the absence of nitroglycerin, and by 36 ± 13, -55 ± 11, and -65 ± 11 in the presence of nitroglycerin. Minimum - dP/dt increased by 65 ± 8, 71 ± 8, and 77 ± 3 in the absence of nitroglycerin, and by 63 ± 7, 71 ± 8, and 78 ± 7 in the presence of nitroglycerin. No significant changes in heart rate were observed; however, widespread ST-segment elevation was observed in all animals. Coronary angiography following carbon dioxide injection revealed a marked decrease in coronary flow velocity until the gas was cleared from the microcirculation. This was also documented by direct measurement of flow velocity using a Doppler catheter in an additional animal. Left ventriculography demonstrated immediate global dilation and depression of systolic function. Conclusions: In the swine model, relatively small doses of intracoronary carbon dioxide cause profound yet reversible global left ventricular dysfunction which appears to be ischemic in origin.
KW - arteriography
KW - contrast media
KW - coronary angiography
KW - ischemia
KW - left ventricular function
UR - http://www.scopus.com/inward/record.url?scp=0029790239&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029790239&partnerID=8YFLogxK
M3 - Article
C2 - 8790949
AN - SCOPUS:0029790239
VL - 19
SP - 461
EP - 465
JO - Clinical Cardiology
JF - Clinical Cardiology
SN - 0160-9289
IS - 6
ER -