Effects of intracoronary carbon dioxide on left ventricular function in swine

Charles R. Lambert, Eduardo De Marchena, Mahesh Bikkina, Brian K. Arcement

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background and hypothesis: Carbon dioxide is currently used as an arterial and venous contrast agent; however, little is known of its effects on left ventricular function. This study was undertaken to investigate those effects. Methods: Ascending doses of 5, 10, and 20 ml of carbon dioxide were administered into the left main coronary artery of domestic swine with and without a continuous infusion of intravenous nitroglycerin (50 μg/min). Results: Carbon dioxide had an immediate and profound depressant effect on both systolic and diastolic left ventricular function associated with ischemic electrocardiographic changes. Compared with controls (% change), ascending doses of carbon dioxide decreased systolic pressure by -35 ± 7, - 48 ± 8, and -53 ± 4 in the absence of nitroglycerin, and by -32 ± 9, -50 ± 9, and -60 ± 9 in the presence of nitroglycerin. Peak +dP/dt decreased by -54 ± 7, -61 ± 11, and -64 ± 3 in the absence of nitroglycerin, and by 36 ± 13, -55 ± 11, and -65 ± 11 in the presence of nitroglycerin. Minimum - dP/dt increased by 65 ± 8, 71 ± 8, and 77 ± 3 in the absence of nitroglycerin, and by 63 ± 7, 71 ± 8, and 78 ± 7 in the presence of nitroglycerin. No significant changes in heart rate were observed; however, widespread ST-segment elevation was observed in all animals. Coronary angiography following carbon dioxide injection revealed a marked decrease in coronary flow velocity until the gas was cleared from the microcirculation. This was also documented by direct measurement of flow velocity using a Doppler catheter in an additional animal. Left ventriculography demonstrated immediate global dilation and depression of systolic function. Conclusions: In the swine model, relatively small doses of intracoronary carbon dioxide cause profound yet reversible global left ventricular dysfunction which appears to be ischemic in origin.

Original languageEnglish
Pages (from-to)461-465
Number of pages5
JournalClinical Cardiology
Volume19
Issue number6
StatePublished - Jun 1 1996

Fingerprint

Nitroglycerin
Left Ventricular Function
Carbon Dioxide
Swine
Left Ventricular Dysfunction
Microcirculation
Coronary Angiography
Intravenous Infusions
Contrast Media
Dilatation
Coronary Vessels
Catheters
Heart Rate
Gases
Blood Pressure
Injections

Keywords

  • arteriography
  • contrast media
  • coronary angiography
  • ischemia
  • left ventricular function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effects of intracoronary carbon dioxide on left ventricular function in swine. / Lambert, Charles R.; De Marchena, Eduardo; Bikkina, Mahesh; Arcement, Brian K.

In: Clinical Cardiology, Vol. 19, No. 6, 01.06.1996, p. 461-465.

Research output: Contribution to journalArticle

Lambert, CR, De Marchena, E, Bikkina, M & Arcement, BK 1996, 'Effects of intracoronary carbon dioxide on left ventricular function in swine', Clinical Cardiology, vol. 19, no. 6, pp. 461-465.
Lambert, Charles R. ; De Marchena, Eduardo ; Bikkina, Mahesh ; Arcement, Brian K. / Effects of intracoronary carbon dioxide on left ventricular function in swine. In: Clinical Cardiology. 1996 ; Vol. 19, No. 6. pp. 461-465.
@article{92bb901874b343358eca97af58420691,
title = "Effects of intracoronary carbon dioxide on left ventricular function in swine",
abstract = "Background and hypothesis: Carbon dioxide is currently used as an arterial and venous contrast agent; however, little is known of its effects on left ventricular function. This study was undertaken to investigate those effects. Methods: Ascending doses of 5, 10, and 20 ml of carbon dioxide were administered into the left main coronary artery of domestic swine with and without a continuous infusion of intravenous nitroglycerin (50 μg/min). Results: Carbon dioxide had an immediate and profound depressant effect on both systolic and diastolic left ventricular function associated with ischemic electrocardiographic changes. Compared with controls ({\%} change), ascending doses of carbon dioxide decreased systolic pressure by -35 ± 7, - 48 ± 8, and -53 ± 4 in the absence of nitroglycerin, and by -32 ± 9, -50 ± 9, and -60 ± 9 in the presence of nitroglycerin. Peak +dP/dt decreased by -54 ± 7, -61 ± 11, and -64 ± 3 in the absence of nitroglycerin, and by 36 ± 13, -55 ± 11, and -65 ± 11 in the presence of nitroglycerin. Minimum - dP/dt increased by 65 ± 8, 71 ± 8, and 77 ± 3 in the absence of nitroglycerin, and by 63 ± 7, 71 ± 8, and 78 ± 7 in the presence of nitroglycerin. No significant changes in heart rate were observed; however, widespread ST-segment elevation was observed in all animals. Coronary angiography following carbon dioxide injection revealed a marked decrease in coronary flow velocity until the gas was cleared from the microcirculation. This was also documented by direct measurement of flow velocity using a Doppler catheter in an additional animal. Left ventriculography demonstrated immediate global dilation and depression of systolic function. Conclusions: In the swine model, relatively small doses of intracoronary carbon dioxide cause profound yet reversible global left ventricular dysfunction which appears to be ischemic in origin.",
keywords = "arteriography, contrast media, coronary angiography, ischemia, left ventricular function",
author = "Lambert, {Charles R.} and {De Marchena}, Eduardo and Mahesh Bikkina and Arcement, {Brian K.}",
year = "1996",
month = "6",
day = "1",
language = "English",
volume = "19",
pages = "461--465",
journal = "Clinical Cardiology",
issn = "0160-9289",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Effects of intracoronary carbon dioxide on left ventricular function in swine

AU - Lambert, Charles R.

AU - De Marchena, Eduardo

AU - Bikkina, Mahesh

AU - Arcement, Brian K.

PY - 1996/6/1

Y1 - 1996/6/1

N2 - Background and hypothesis: Carbon dioxide is currently used as an arterial and venous contrast agent; however, little is known of its effects on left ventricular function. This study was undertaken to investigate those effects. Methods: Ascending doses of 5, 10, and 20 ml of carbon dioxide were administered into the left main coronary artery of domestic swine with and without a continuous infusion of intravenous nitroglycerin (50 μg/min). Results: Carbon dioxide had an immediate and profound depressant effect on both systolic and diastolic left ventricular function associated with ischemic electrocardiographic changes. Compared with controls (% change), ascending doses of carbon dioxide decreased systolic pressure by -35 ± 7, - 48 ± 8, and -53 ± 4 in the absence of nitroglycerin, and by -32 ± 9, -50 ± 9, and -60 ± 9 in the presence of nitroglycerin. Peak +dP/dt decreased by -54 ± 7, -61 ± 11, and -64 ± 3 in the absence of nitroglycerin, and by 36 ± 13, -55 ± 11, and -65 ± 11 in the presence of nitroglycerin. Minimum - dP/dt increased by 65 ± 8, 71 ± 8, and 77 ± 3 in the absence of nitroglycerin, and by 63 ± 7, 71 ± 8, and 78 ± 7 in the presence of nitroglycerin. No significant changes in heart rate were observed; however, widespread ST-segment elevation was observed in all animals. Coronary angiography following carbon dioxide injection revealed a marked decrease in coronary flow velocity until the gas was cleared from the microcirculation. This was also documented by direct measurement of flow velocity using a Doppler catheter in an additional animal. Left ventriculography demonstrated immediate global dilation and depression of systolic function. Conclusions: In the swine model, relatively small doses of intracoronary carbon dioxide cause profound yet reversible global left ventricular dysfunction which appears to be ischemic in origin.

AB - Background and hypothesis: Carbon dioxide is currently used as an arterial and venous contrast agent; however, little is known of its effects on left ventricular function. This study was undertaken to investigate those effects. Methods: Ascending doses of 5, 10, and 20 ml of carbon dioxide were administered into the left main coronary artery of domestic swine with and without a continuous infusion of intravenous nitroglycerin (50 μg/min). Results: Carbon dioxide had an immediate and profound depressant effect on both systolic and diastolic left ventricular function associated with ischemic electrocardiographic changes. Compared with controls (% change), ascending doses of carbon dioxide decreased systolic pressure by -35 ± 7, - 48 ± 8, and -53 ± 4 in the absence of nitroglycerin, and by -32 ± 9, -50 ± 9, and -60 ± 9 in the presence of nitroglycerin. Peak +dP/dt decreased by -54 ± 7, -61 ± 11, and -64 ± 3 in the absence of nitroglycerin, and by 36 ± 13, -55 ± 11, and -65 ± 11 in the presence of nitroglycerin. Minimum - dP/dt increased by 65 ± 8, 71 ± 8, and 77 ± 3 in the absence of nitroglycerin, and by 63 ± 7, 71 ± 8, and 78 ± 7 in the presence of nitroglycerin. No significant changes in heart rate were observed; however, widespread ST-segment elevation was observed in all animals. Coronary angiography following carbon dioxide injection revealed a marked decrease in coronary flow velocity until the gas was cleared from the microcirculation. This was also documented by direct measurement of flow velocity using a Doppler catheter in an additional animal. Left ventriculography demonstrated immediate global dilation and depression of systolic function. Conclusions: In the swine model, relatively small doses of intracoronary carbon dioxide cause profound yet reversible global left ventricular dysfunction which appears to be ischemic in origin.

KW - arteriography

KW - contrast media

KW - coronary angiography

KW - ischemia

KW - left ventricular function

UR - http://www.scopus.com/inward/record.url?scp=0029790239&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029790239&partnerID=8YFLogxK

M3 - Article

VL - 19

SP - 461

EP - 465

JO - Clinical Cardiology

JF - Clinical Cardiology

SN - 0160-9289

IS - 6

ER -