Effects of interleukin 4 on neonatal B lymphocyte tolerance

Valerian B. Pinto, Richard L. Riley, James S. Peacock

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Perturbation of antigen receptors on mouse neonatal B cells by rabbit anti-mouse IgM antibody was shown to inhibit cell proliferation in response to the B cell mitogen lipopolysaccharide. When these antibody-inactivated cells were challenged with lipopolysaccharide in the presence of the helper T cell product interleukin 4, a strong proliferative response was observed. Interleukin 4 alone did not cause proliferation of the antibody-treated B cells. Pretreatment with interleukin 4 did not prevent neonatal B cell inactivation by the antibody. Our results show that neonatal B cells inactivated directly through their antigen receptors can be reactivated by the combined signals of interleukin 4 and lipopolysaccharide.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalBiochemical and biophysical research communications
Volume164
Issue number1
DOIs
StatePublished - Oct 16 1989
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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