Effects of interleukin 4 on neonatal B lymphocyte tolerance

Valerian B. Pinto, Richard L Riley, James S. Peacock

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Perturbation of antigen receptors on mouse neonatal B cells by rabbit anti-mouse IgM antibody was shown to inhibit cell proliferation in response to the B cell mitogen lipopolysaccharide. When these antibody-inactivated cells were challenged with lipopolysaccharide in the presence of the helper T cell product interleukin 4, a strong proliferative response was observed. Interleukin 4 alone did not cause proliferation of the antibody-treated B cells. Pretreatment with interleukin 4 did not prevent neonatal B cell inactivation by the antibody. Our results show that neonatal B cells inactivated directly through their antigen receptors can be reactivated by the combined signals of interleukin 4 and lipopolysaccharide.

Original languageEnglish
Pages (from-to)199-204
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume164
Issue number1
DOIs
StatePublished - Oct 16 1989
Externally publishedYes

Fingerprint

Lymphocytes
Interleukin-4
B-Lymphocytes
Cells
Lipopolysaccharides
Antigen Receptors
Antibodies
T-cells
Cell proliferation
Helper-Inducer T-Lymphocytes
Mitogens
Immunoglobulin M
Cell Proliferation
Rabbits

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Effects of interleukin 4 on neonatal B lymphocyte tolerance. / Pinto, Valerian B.; Riley, Richard L; Peacock, James S.

In: Biochemical and Biophysical Research Communications, Vol. 164, No. 1, 16.10.1989, p. 199-204.

Research output: Contribution to journalArticle

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