Effects of inducible beta-lactamase and antimicrobial resistance upon the activity of newer beta-lactam antibiotics against Pseudomonas aeruginosa

T. A. Hoffman, Timothy Cleary, D. H. Bercuson

Research output: Contribution to journalArticle

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Abstract

The activity of carbenicillin, ticarcillin, piperacillin, cefotaxime, moxalactam, and N-formimidoyl thienamycin was evaluated against 262 clinical isolates of Pseudomonas aeruginosa. There were 242 (92%) of the isolates that were susceptible to carbenicillin or ticarcillin by an agar dilution method. Against this population of susceptible isolates, the median MICs were 1.56 μg/ml of N-formimidoyl thienamycin, 3.13 μg/ml of piperacillin, 25 μg/ml of ticarcillin, 25 μg/ml of cefotaxime, 50 μg/ml of carbenicillin and 50 μg/ml of moxalactam. N-Formimidoyl thienamycin was the only beta-lactam antibiotic not affected by an inducible betalactamase detected in 24 randomly selected susceptible isolates by a disk approximation assay, while cefotaxime was inactivated to a greater extent than any of the other beta-lactam antibiotics. Resistance to carbenicillin and ticarcillin was noted in 20 isolates (8%); these were susceptible to N-formimidoyl thienamycin, but cross-resistance with piperacillin, cefotaxime, and moxalactam was frequent. Only four of these resistant isolates were found to have a constitutive beta-lactamase. Gentamicin resistance occurred in 51 isolates (19%) and was an independent variable of resistance to the beta-lactam drugs.

Original languageEnglish
Pages (from-to)1334-1340
Number of pages7
JournalJournal of Antibiotics
Volume34
Issue number10
StatePublished - Dec 1 1981

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Ticarcillin
Carbenicillin
Cefotaxime
beta-Lactams
Moxalactam
beta-Lactamases
Pseudomonas aeruginosa
Piperacillin
Anti-Bacterial Agents
beta-Lactam Resistance
Gentamicins
Agar
thienamycin
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Effects of inducible beta-lactamase and antimicrobial resistance upon the activity of newer beta-lactam antibiotics against Pseudomonas aeruginosa. / Hoffman, T. A.; Cleary, Timothy; Bercuson, D. H.

In: Journal of Antibiotics, Vol. 34, No. 10, 01.12.1981, p. 1334-1340.

Research output: Contribution to journalArticle

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