Lesions in the hypothalamus of female CBA mice were produced by administration of gold thioglucose (GTG). Hypophysectomy in groups of GTG lesioned mice (GTG/Hypex) and in normal mice (Hypex/Norm) was performed 4 days after GTG treatment. A significant increase in body weight and total body fat was seen only in the intact GTG-treated mice. Uptake of I-131 by the thyroid gland and adrenal weights were significantly decreased in the GTG/Hypex and Hypex/Norm mice. These data suggest that the pituitary may play an important role in production of hypothalamic obesity in mice.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Mar 1966|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)