Effects of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH on passive and active avoidance behavior and on open-field activity of rats

László Vécsei, Gyula Telegdy, Andrew V. Schally, David H. Coy

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The action of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH on the passive and active avoidance behavior and open-field activity of rats was studied after peripheral and intracerebroventricular administration. When applied before the test session, intracerebroventricular administration increased the avoidance latency of passive avoidance behavior. Subcutaneous, intraperitoneal and intracerebroventricular administration of the peptide delayed the extinction of active avoidance behavior. Both subcutaneous and intracerebroventricula administration increased the grooming activity of the rats. The data suggest that H-Phe-Ile-Try-His-Ser-Tyr-Lys-OH is able to influence memory, acting mainly on the retrieval processes, ad to modify open-field activity.

Original languageEnglish (US)
Pages (from-to)633-637
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume17
Issue number4
DOIs
StatePublished - Oct 1982
Externally publishedYes

Keywords

  • Avoidance behavior
  • H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH
  • Open-field activity

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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