@article{d74c2850e3114a6baf00beea3931a2dd,
title = "EFFECTS OF GROWTH-HORMONE RELEASE-INHIBITING HORMONE ON CIRCULATING GLUCAGON, INSULIN, AND GROWTH HORMONE IN NORMAL, DIABETIC, ACROMEGALIC, AND HYPOPITUITARY PATIENTS",
abstract = "Growth-hormone release-inhibiting hormone (G.H.-R.I.H.) impairs the release of glucagon and insulin as well as G.H. during oral glucose tolerance and intravenous arginine tests; patients with acromegaly, diabetes mellitus, and hypopituitarism as well as healthy individuals were studied. Reciprocal changes in non-esterified fatty acids and plasma-insulin were seen. During the glucose-tolerance tests the rise in plasma-glucose was delayed and the peak values were often higher and more sustained after G.H.-R.I.H. than in control studies, so that glucose tolerance was impaired. Plasma-glucagon levels were suppressed by G.H.-R.I.H. in a patient with a glucagon-secreting tumour.",
author = "Mortimer, {C. H.} and D. Carr and T. Lind and Bloom, {S. R.} and Mallinson, {C. N.} and Schally, {A. V.} and Tunbridge, {W. M.G.} and Lynne Yeomans and Coy, {D. H.} and A. Kastin and Besser, {G. M.} and R. Hall",
note = "Funding Information: We thank the department of clinical biochemistry and in particulary Dr M. J. Watson, Royal Victoria Infirmary, New- castle upon Tyne, the staff of the metabolic unit, St. Barthol-omew{\textquoteright}s Hospital, and the Institute of Clinical Research, Middlesex Hospital. The studies have been supported by the Joint Research Board of St. Bartholomew{\textquoteright}s Hospital and the Peel Medical Research Trust. S.R.B. is in receipt of a M.R.C. clinical fellowship and is supported by the British Diabetic Association. Requests for reprints should be addressed to R. H., Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NEI 4LP.",
year = "1974",
month = apr,
day = "20",
doi = "10.1016/S0140-6736(74)92903-1",
language = "English (US)",
volume = "303",
pages = "697--701",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "7860",
}