EFFECTS OF GROWTH-HORMONE RELEASE-INHIBITING HORMONE ON CIRCULATING GLUCAGON, INSULIN, AND GROWTH HORMONE IN NORMAL, DIABETIC, ACROMEGALIC, AND HYPOPITUITARY PATIENTS

C. H. Mortimer, D. Carr, T. Lind, S. R. Bloom, C. N. Mallinson, A. V. Schally, W. M.G. Tunbridge, Lynne Yeomans, D. H. Coy, A. Kastin, G. M. Besser, R. Hall

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195 Scopus citations

Abstract

Growth-hormone release-inhibiting hormone (G.H.-R.I.H.) impairs the release of glucagon and insulin as well as G.H. during oral glucose tolerance and intravenous arginine tests; patients with acromegaly, diabetes mellitus, and hypopituitarism as well as healthy individuals were studied. Reciprocal changes in non-esterified fatty acids and plasma-insulin were seen. During the glucose-tolerance tests the rise in plasma-glucose was delayed and the peak values were often higher and more sustained after G.H.-R.I.H. than in control studies, so that glucose tolerance was impaired. Plasma-glucagon levels were suppressed by G.H.-R.I.H. in a patient with a glucagon-secreting tumour.

Original languageEnglish (US)
Pages (from-to)697-701
Number of pages5
JournalThe Lancet
Volume303
Issue number7860
DOIs
StatePublished - Apr 20 1974
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Mortimer, C. H., Carr, D., Lind, T., Bloom, S. R., Mallinson, C. N., Schally, A. V., Tunbridge, W. M. G., Yeomans, L., Coy, D. H., Kastin, A., Besser, G. M., & Hall, R. (1974). EFFECTS OF GROWTH-HORMONE RELEASE-INHIBITING HORMONE ON CIRCULATING GLUCAGON, INSULIN, AND GROWTH HORMONE IN NORMAL, DIABETIC, ACROMEGALIC, AND HYPOPITUITARY PATIENTS. The Lancet, 303(7860), 697-701. https://doi.org/10.1016/S0140-6736(74)92903-1