EFFECTS OF GROWTH-HORMONE RELEASE-INHIBITING HORMONE ON CIRCULATING GLUCAGON, INSULIN, AND GROWTH HORMONE IN NORMAL, DIABETIC, ACROMEGALIC, AND HYPOPITUITARY PATIENTS

C. H. Mortimer; D. Carr; T. Lind; S. R. Bloom; C. N. Mallinson; A. V. Schally; W. M.G. Tunbridge; Lynne Yeomans; D. H. Coy; A. Kastin; G. M. Besser; R. Hall

doi:10.1016/S0140-6736(74)92903-1

EFFECTS OF GROWTH-HORMONE RELEASE-INHIBITING HORMONE ON CIRCULATING GLUCAGON, INSULIN, AND GROWTH HORMONE IN NORMAL, DIABETIC, ACROMEGALIC, AND HYPOPITUITARY PATIENTS

C. H. Mortimer, D. Carr, T. Lind, S. R. Bloom, C. N. Mallinson, A. V. Schally, W. M.G. Tunbridge, Lynne Yeomans, D. H. Coy, A. Kastin, G. M. Besser, R. Hall

Research output: Contribution to journal › Article › peer-review

195 Scopus citations

Abstract

Growth-hormone release-inhibiting hormone (G.H.-R.I.H.) impairs the release of glucagon and insulin as well as G.H. during oral glucose tolerance and intravenous arginine tests; patients with acromegaly, diabetes mellitus, and hypopituitarism as well as healthy individuals were studied. Reciprocal changes in non-esterified fatty acids and plasma-insulin were seen. During the glucose-tolerance tests the rise in plasma-glucose was delayed and the peak values were often higher and more sustained after G.H.-R.I.H. than in control studies, so that glucose tolerance was impaired. Plasma-glucagon levels were suppressed by G.H.-R.I.H. in a patient with a glucagon-secreting tumour.

Original language	English (US)
Pages (from-to)	697-701
Number of pages	5
Journal	The Lancet
Volume	303
Issue number	7860
DOIs	https://doi.org/10.1016/S0140-6736(74)92903-1
State	Published - Apr 20 1974
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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Mortimer, C. H., Carr, D., Lind, T., Bloom, S. R., Mallinson, C. N., Schally, A. V., Tunbridge, W. M. G., Yeomans, L., Coy, D. H., Kastin, A., Besser, G. M., & Hall, R. (1974). EFFECTS OF GROWTH-HORMONE RELEASE-INHIBITING HORMONE ON CIRCULATING GLUCAGON, INSULIN, AND GROWTH HORMONE IN NORMAL, DIABETIC, ACROMEGALIC, AND HYPOPITUITARY PATIENTS. The Lancet, 303(7860), 697-701. https://doi.org/10.1016/S0140-6736(74)92903-1

EFFECTS OF GROWTH-HORMONE RELEASE-INHIBITING HORMONE ON CIRCULATING GLUCAGON, INSULIN, AND GROWTH HORMONE IN NORMAL, DIABETIC, ACROMEGALIC, AND HYPOPITUITARY PATIENTS. / Mortimer, C. H.; Carr, D.; Lind, T.; Bloom, S. R.; Mallinson, C. N.; Schally, A. V.; Tunbridge, W. M.G.; Yeomans, Lynne; Coy, D. H.; Kastin, A.; Besser, G. M.; Hall, R.

In: The Lancet, Vol. 303, No. 7860, 20.04.1974, p. 697-701.

Research output: Contribution to journal › Article › peer-review

Mortimer, CH, Carr, D, Lind, T, Bloom, SR, Mallinson, CN, Schally, AV, Tunbridge, WMG, Yeomans, L, Coy, DH, Kastin, A, Besser, GM & Hall, R 1974, 'EFFECTS OF GROWTH-HORMONE RELEASE-INHIBITING HORMONE ON CIRCULATING GLUCAGON, INSULIN, AND GROWTH HORMONE IN NORMAL, DIABETIC, ACROMEGALIC, AND HYPOPITUITARY PATIENTS', The Lancet, vol. 303, no. 7860, pp. 697-701. https://doi.org/10.1016/S0140-6736(74)92903-1

Mortimer, C. H. ; Carr, D. ; Lind, T. ; Bloom, S. R. ; Mallinson, C. N. ; Schally, A. V. ; Tunbridge, W. M.G. ; Yeomans, Lynne ; Coy, D. H. ; Kastin, A. ; Besser, G. M. ; Hall, R. / EFFECTS OF GROWTH-HORMONE RELEASE-INHIBITING HORMONE ON CIRCULATING GLUCAGON, INSULIN, AND GROWTH HORMONE IN NORMAL, DIABETIC, ACROMEGALIC, AND HYPOPITUITARY PATIENTS. In: The Lancet. 1974 ; Vol. 303, No. 7860. pp. 697-701.

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