Abstract
Growth-hormone release-inhibiting hormone (G.H.-R.I.H.) impairs the release of glucagon and insulin as well as G.H. during oral glucose tolerance and intravenous arginine tests; patients with acromegaly, diabetes mellitus, and hypopituitarism as well as healthy individuals were studied. Reciprocal changes in non-esterified fatty acids and plasma-insulin were seen. During the glucose-tolerance tests the rise in plasma-glucose was delayed and the peak values were often higher and more sustained after G.H.-R.I.H. than in control studies, so that glucose tolerance was impaired. Plasma-glucagon levels were suppressed by G.H.-R.I.H. in a patient with a glucagon-secreting tumour.
| Original language | English |
|---|---|
| Pages (from-to) | 697-701 |
| Number of pages | 5 |
| Journal | The Lancet |
| Volume | 303 |
| Issue number | 7860 |
| DOIs | |
| State | Published - Apr 20 1974 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
EFFECTS OF GROWTH-HORMONE RELEASE-INHIBITING HORMONE ON CIRCULATING GLUCAGON, INSULIN, AND GROWTH HORMONE IN NORMAL, DIABETIC, ACROMEGALIC, AND HYPOPITUITARY PATIENTS. / Mortimer, C. H.; Carr, D.; Lind, T.; Bloom, S. R.; Mallinson, C. N.; Schally, Andrew V; Tunbridge, W. M G; Yeomans, Lynne; Coy, D. H.; Kastin, A.; Besser, G. M.; Hall, R.
In: The Lancet, Vol. 303, No. 7860, 20.04.1974, p. 697-701.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - EFFECTS OF GROWTH-HORMONE RELEASE-INHIBITING HORMONE ON CIRCULATING GLUCAGON, INSULIN, AND GROWTH HORMONE IN NORMAL, DIABETIC, ACROMEGALIC, AND HYPOPITUITARY PATIENTS
AU - Mortimer, C. H.
AU - Carr, D.
AU - Lind, T.
AU - Bloom, S. R.
AU - Mallinson, C. N.
AU - Schally, Andrew V
AU - Tunbridge, W. M G
AU - Yeomans, Lynne
AU - Coy, D. H.
AU - Kastin, A.
AU - Besser, G. M.
AU - Hall, R.
PY - 1974/4/20
Y1 - 1974/4/20
N2 - Growth-hormone release-inhibiting hormone (G.H.-R.I.H.) impairs the release of glucagon and insulin as well as G.H. during oral glucose tolerance and intravenous arginine tests; patients with acromegaly, diabetes mellitus, and hypopituitarism as well as healthy individuals were studied. Reciprocal changes in non-esterified fatty acids and plasma-insulin were seen. During the glucose-tolerance tests the rise in plasma-glucose was delayed and the peak values were often higher and more sustained after G.H.-R.I.H. than in control studies, so that glucose tolerance was impaired. Plasma-glucagon levels were suppressed by G.H.-R.I.H. in a patient with a glucagon-secreting tumour.
AB - Growth-hormone release-inhibiting hormone (G.H.-R.I.H.) impairs the release of glucagon and insulin as well as G.H. during oral glucose tolerance and intravenous arginine tests; patients with acromegaly, diabetes mellitus, and hypopituitarism as well as healthy individuals were studied. Reciprocal changes in non-esterified fatty acids and plasma-insulin were seen. During the glucose-tolerance tests the rise in plasma-glucose was delayed and the peak values were often higher and more sustained after G.H.-R.I.H. than in control studies, so that glucose tolerance was impaired. Plasma-glucagon levels were suppressed by G.H.-R.I.H. in a patient with a glucagon-secreting tumour.
UR - http://www.scopus.com/inward/record.url?scp=0015952818&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015952818&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(74)92903-1
DO - 10.1016/S0140-6736(74)92903-1
M3 - Article
C2 - 4132421
AN - SCOPUS:0015952818
VL - 303
SP - 697
EP - 701
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 7860
ER -