Effects of fluid load on human urine characteristics related to workplace drug testing

Arvind K. Chaturvedi, Jim L. Sershon, Kristi J. Craft, Patrick S. Cardona, John W. Soper, Dennis V. Canfield, Kurt M. Dubowski, James E. Whinnery, Misti J. Leyva, Christopher E. Aston, Steve M. Blevins, Jonelle Wright, Albert D. Fraser, David J. Kuntz

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

During workplace drug testing, urine is tested for dilution, substitution and adulteration. Donors argue that these findings are due to medical, health or working conditions or diet and genetic differences. There is a paucity of data correlating changes in urine characteristics after a fluid load to various body parameters. Therefore, five urine specimens (one in the morning, one prior to drinking 800 mL of a beverage, and three time intervals thereafter) from 12 males and 12 females were tested for four different beverages on separate occasions. Of the 480 samples, 376 were in sufficient amounts. Of these 376, 36 (10%) had creatinine <20 mg/dL but ≥2 mg/dL; 27 (75%) of 36 had specific gravity <1.0030 but >1.0010. Thus, these 27 samples can be considered to be dilute; 20 (74%) of 27 were from females. For males with at least one dilute sample, body fat was 11% less and resting metabolic rate (RMR) was 29% more than males with no dilute samples (p > 0.05); for females with at least one dilute sample, height was 8% less and weight 20% less than females with no dilute samples (p > 0.05). Individuals with a higher RMR appear to have a greater potential for producing dilute urine specimens than those with a lower RMR. Thus, a dilute sample does not necessarily indicate that it was intentionally diluted. Such samples must be carefully evaluated in consideration with recent consumption of liquid by donors to avoid false accusations.

Original languageEnglish
Article numberbks082
Pages (from-to)5-10
Number of pages6
JournalJournal of Analytical Toxicology
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Beverages
workplace
Basal Metabolism
Workplace
urine
drug
Urine
Fluids
fluid
Testing
Nutrition
Oils and fats
Pharmaceutical Preparations
Dilution
Creatinine
Substitution reactions
Fats
Health
working conditions
Liquids

ASJC Scopus subject areas

  • Analytical Chemistry
  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Chemical Health and Safety
  • Environmental Chemistry

Cite this

Chaturvedi, A. K., Sershon, J. L., Craft, K. J., Cardona, P. S., Soper, J. W., Canfield, D. V., ... Kuntz, D. J. (2013). Effects of fluid load on human urine characteristics related to workplace drug testing. Journal of Analytical Toxicology, 37(1), 5-10. [bks082]. https://doi.org/10.1093/jat/bks082

Effects of fluid load on human urine characteristics related to workplace drug testing. / Chaturvedi, Arvind K.; Sershon, Jim L.; Craft, Kristi J.; Cardona, Patrick S.; Soper, John W.; Canfield, Dennis V.; Dubowski, Kurt M.; Whinnery, James E.; Leyva, Misti J.; Aston, Christopher E.; Blevins, Steve M.; Wright, Jonelle; Fraser, Albert D.; Kuntz, David J.

In: Journal of Analytical Toxicology, Vol. 37, No. 1, bks082, 01.01.2013, p. 5-10.

Research output: Contribution to journalArticle

Chaturvedi, AK, Sershon, JL, Craft, KJ, Cardona, PS, Soper, JW, Canfield, DV, Dubowski, KM, Whinnery, JE, Leyva, MJ, Aston, CE, Blevins, SM, Wright, J, Fraser, AD & Kuntz, DJ 2013, 'Effects of fluid load on human urine characteristics related to workplace drug testing', Journal of Analytical Toxicology, vol. 37, no. 1, bks082, pp. 5-10. https://doi.org/10.1093/jat/bks082
Chaturvedi AK, Sershon JL, Craft KJ, Cardona PS, Soper JW, Canfield DV et al. Effects of fluid load on human urine characteristics related to workplace drug testing. Journal of Analytical Toxicology. 2013 Jan 1;37(1):5-10. bks082. https://doi.org/10.1093/jat/bks082
Chaturvedi, Arvind K. ; Sershon, Jim L. ; Craft, Kristi J. ; Cardona, Patrick S. ; Soper, John W. ; Canfield, Dennis V. ; Dubowski, Kurt M. ; Whinnery, James E. ; Leyva, Misti J. ; Aston, Christopher E. ; Blevins, Steve M. ; Wright, Jonelle ; Fraser, Albert D. ; Kuntz, David J. / Effects of fluid load on human urine characteristics related to workplace drug testing. In: Journal of Analytical Toxicology. 2013 ; Vol. 37, No. 1. pp. 5-10.
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