Effects of fish oil supplementation on apolipoprotein B100 production and lipoprotein metabolism in normolipidaemic males

P. Bordin, O. A F Bodamer, S. Venkatesan, R. M. Gray, P. A. Bannister, D. Halliday

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Objective: To evaluate the effects of four weeks of fish oil supplementation on apolipoprotein B100 production and lipoprotein metabolism in normolipidaemic males. Design and subjects: Very low density lipoprotein (VLDL) apolipoprotein B100 (apoB100) kinetics in ten healthy, white males, aged 22-43 y (mean 32 y) were investigated using a 13C-leucine technique and gas chromatography-mass spectrometry before and after fish oil supplementation. Intervention: All subjects received 10 g (1.8 g EPA, 1.2 g DHA)/d of fish oil concentrate for four weeks. Results: Fish oil supplementation resulted in a decrease of total plasma VLDL (mean ± s.d. 1.11 ± 0.41 vs 0.87 ± 0.28 mmol/l, P < 0.05) and triacylglycerol concentrations (0.74 ± 0.27 vs 0.48 ± 0.21 mmol/l, P < 0.01). VLDL apoB100 pool size was decreased without alteration of the fractional synthetic rate but a significant decrease of apoB100 production (2.23 ± 0.90 vs 1.54 ± 0.52 mg/dl/h, P < 0.02). Following fish oil supplementation plasma concentrations of glucose and insulin as well as lipoprotein and hepatic lipase activities were unchanged. Fasting plasma concentrations of non-esterified fatty acid (NEFA) were decreased (0.45 ± 0.12 vs 0.33 ± 0.10 mmol/l, P < 0.05). Conclusions: Dietary supplementation with fish oil in healthy males results in decreased VLDL-triacylglycerol concentrations through a decrease in VLDL particle synthesis. The decrease in NEFA substrate supply also contributes.

Original languageEnglish
Pages (from-to)104-109
Number of pages6
JournalEuropean Journal of Clinical Nutrition
Volume52
Issue number2
StatePublished - Feb 1 1998

Fingerprint

apolipoproteins
Fish Oils
Apolipoproteins
fish oils
VLDL Lipoproteins
very low density lipoprotein
lipoproteins
Lipoproteins
metabolism
free fatty acids
Triglycerides
Fatty Acids
triacylglycerols
Lipoprotein Lipase
Dietary Supplements
Leucine
Gas Chromatography-Mass Spectrometry
leucine
fasting
dietary supplements

Keywords

  • apoB100
  • Fish oil
  • Lipoprotein
  • Mass spectrometry
  • n-3 fatty acids
  • Stable isotopes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Bordin, P., Bodamer, O. A. F., Venkatesan, S., Gray, R. M., Bannister, P. A., & Halliday, D. (1998). Effects of fish oil supplementation on apolipoprotein B100 production and lipoprotein metabolism in normolipidaemic males. European Journal of Clinical Nutrition, 52(2), 104-109.

Effects of fish oil supplementation on apolipoprotein B100 production and lipoprotein metabolism in normolipidaemic males. / Bordin, P.; Bodamer, O. A F; Venkatesan, S.; Gray, R. M.; Bannister, P. A.; Halliday, D.

In: European Journal of Clinical Nutrition, Vol. 52, No. 2, 01.02.1998, p. 104-109.

Research output: Contribution to journalArticle

Bordin, P, Bodamer, OAF, Venkatesan, S, Gray, RM, Bannister, PA & Halliday, D 1998, 'Effects of fish oil supplementation on apolipoprotein B100 production and lipoprotein metabolism in normolipidaemic males', European Journal of Clinical Nutrition, vol. 52, no. 2, pp. 104-109.
Bordin, P. ; Bodamer, O. A F ; Venkatesan, S. ; Gray, R. M. ; Bannister, P. A. ; Halliday, D. / Effects of fish oil supplementation on apolipoprotein B100 production and lipoprotein metabolism in normolipidaemic males. In: European Journal of Clinical Nutrition. 1998 ; Vol. 52, No. 2. pp. 104-109.
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AU - Bannister, P. A.

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