Effects of exogenous interferon in cytomegalovirus infections complicating bone marrow transplantation

Richard J. O'Reilly, Lloyd K. Everson, Gabriel Emödi, John Hansen, Elizabeth M. Smithwick, Elena Grimes, Savita Pahwa, Rajandra Pahwa, Stanley Schwartz, Donald Armstrong, Frederick P. Siegal, Sudhir Gupta, Bo Dupont, Robert A. Good

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Human leukocyte interferon was administered to two patients with cytomegalovirus infection which developed following allogeneic bone marrow transplantation. In one patient with hepatitis and evidence of concurrent graft-vs-host disease, significant clinical improvement and disappearance of viremia was observed. Interferon therapy was associated with suppression of lymphocyte responses to mitogens and, in one case, with a decrease of complement-fixing antibody titers to cytomegalovirus. Other immunologic parameters were unchanged. No suppression of marrow engraftment was observed.

Original languageEnglish (US)
Pages (from-to)51-61
Number of pages11
JournalClinical Immunology and Immunopathology
Volume6
Issue number1
DOIs
StatePublished - Jul 1976

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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