Human leukocyte interferon was administered to two patients with cytomegalovirus infection which developed following allogeneic bone marrow transplantation. In one patient with hepatitis and evidence of concurrent graft-vs-host disease, significant clinical improvement and disappearance of viremia was observed. Interferon therapy was associated with suppression of lymphocyte responses to mitogens and, in one case, with a decrease of complement-fixing antibody titers to cytomegalovirus. Other immunologic parameters were unchanged. No suppression of marrow engraftment was observed.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine