Effects of exercise on muscle activation and metabolism in multiple sclerosis

Jane A. Kent‐Braun, Khema R. Sharma, Michael W. Weiner, Robert G. Miller

Research output: Contribution to journalArticlepeer-review

108 Scopus citations


We investigated the role of metabolism in muscle fatigue during voluntary exercise in persons with mild multiple sclerosis (MS). Six MS and 8 healthy control subjects performed intermittent, progressive, isometric contractions of the ankle dorsiflexors, during which we measured maximum voluntary force (MVC), inorganic phosphate (Pi), phosphocreatine (PCr), and pH. During exercise, MVC fell sooner in MS, but by the end of exercise the relative decrease in MVC was similar in both groups. In contrast, at the end of exercise Pi/PCr increased to 1.86 ± 0.22 in controls but only 0.66 ± 0.04 in MS (P < 0.01); likewise, pH was 6.75 ± 0.04 in controls and unchanged (7.06 ± 0.04) in MS (P < 0.01). The smaller metabolic change at the same relative exercise intensity suggests a failure of muscle activation that is present even in mild MS. Neurophysiologic measures of activation indicated some central activation failure and no neuromuscular junction impairment in MS, and suggested that activation failure beyond the muscle membrane (excitation-contraction coupling) may be important in MS. We conclude that metabolic factors do not play a significant role in the development of muscle fatigue during voluntary exercise in mild MS.

Original languageEnglish (US)
Pages (from-to)1162-1169
Number of pages8
JournalMuscle & Nerve
Issue number10
StatePublished - Oct 1994
Externally publishedYes


  • excitation- contraction coupling
  • fatigue
  • magnetic resonance spectroscopy
  • neurophysiology

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


Dive into the research topics of 'Effects of exercise on muscle activation and metabolism in multiple sclerosis'. Together they form a unique fingerprint.

Cite this