Effects of Exercise Mode on Postprandial Metabolism in Humans with Chronic Paraplegia

David W. McMillan, Jennifer L. Maher, Kevin A. Jacobs, Armando J. Mendez, Mark S. Nash, James L.J. Bilzon

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose The purpose of this study was to assess the acute effects of exercise mode and intensity on postprandial macronutrient metabolism. Methods Ten healthy men age 39 ± 10 yr with chronic paraplegia (13.2 ± 8.8 yr, ASIA A-C) completed three isocaloric bouts of upper-body exercise and a resting control. After an overnight fast, participants completed circuit resistance exercise (CRE) first and the following conditions in a randomized order, separated by >48 h: i) control (CON), 45-min seated rest; ii) moderate-intensity continuous exercise (MICE), 40-min arm cranking at a resistance equivalent to 30% peak power output (PPO); and iii) high-intensity interval exercise (HIIE), 30 min arm cranking with resistance alternating every 2 min between 10% PPO and 70% PPO. After each condition, participants completed a mixed-meal tolerance test consisting of a 2510-kJ liquid meal (35% fat, 50% carbohydrate, 15% protein). Blood and expired gas samples were collected at baseline and regular intervals for 150 min after a meal. Results An interaction (P < 0.001) was observed, with rates of lipid oxidation elevated above CON in HIIE until 60 min after a meal and in CRE at all postprandial time points up to 150 min after a meal. Postprandial blood glycerol was greater in MICE (P = 0.020) and CRE (P = 0.001) compared with CON. Furthermore, nonesterified fatty acid area under the curve had a moderate-To-strong effect in CRE versus MICE and HIIE (Cohen's d =-0.76 and-0.50, respectively). Conclusions In persons with paraplegia, high-intensity exercise increased postprandial energy expenditure independent of the energy cost of exercise. Furthermore, exercise combining resistance and endurance modes (CRE) showed the greater effect on postprandial lipid oxidation.

Original languageEnglish (US)
Pages (from-to)1495-1504
Number of pages10
JournalMedicine and science in sports and exercise
Volume53
Issue number7
DOIs
StatePublished - 2021

Keywords

  • CIRCUIT RESISTANCE EXERCISE
  • EXERCISE INTENSITY
  • INTERVAL EXERCISE
  • MIXED-MEAL TOLERANCE TEST
  • SPINAL CORD INJURY
  • UPPER-BODY EXERCISE

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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