Effects of epinephrine on the cardiorespiratory response to hypoxia in sedated newborn piglets with intact and denervated carotid bodies

Cleide Suguihara, Dorothy Hehre, Eduardo Bancalari

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In order to evaluate the effects of epinephrine on the cardiorespiratory response to hypoxia in the neonate, 35 sedated, spontaneously breathing newborn piglets (X̄ ± SD, age 5 ± 0.8 days; weight 1.6 ± 0.3 kg) with intact (ICB) or denervated (DCB) carotid bodies were studied before and during an infusion of saline or epinephrine (2.2 ± 1.0 μg/kg/min, i.v.). Cardiorespiratory measurements were performed while the animals breathed room air and after 10 min of hypoxia (FiO2 0.10) during saline or epinephrine infusion. During epinephrine infusion, the ICB animals had a sustained increase in minute ventilation during hypoxia while the control group showed a biphasic ventilatory response with depression during sustained hypoxia. After the chemodenervation, the ventilatory response to hypoxia was completely blunted in saline and epinephrine animals. In the ICE and DCB animals, the arterial blood pressure decreased significantly with hypoxia during epinephrine infusion, while cardiac output increased significantly in all ICE and DCB saline animals. The oxygen consumption (V̇O2) decreased significantly after 10 min of hypoxia in all groups except in the ICE epinephrine animals, in whom the V̇O2 did not change with hypoxia. In conclusion, the administration of epinephrine to newborn piglets reverses the depressed ventilatory response to hypoxia and this effect requires the activity of the peripheral chemoreceptors.

Original languageEnglish (US)
Pages (from-to)352-359
Number of pages8
JournalNeonatology
Volume67
Issue number5
DOIs
StatePublished - Jan 1 1995

Keywords

  • Adrenergic receptors
  • Breathing control
  • Cardiorespiratory measurements
  • Hypoxemia
  • Peripheral chemoreceptors

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

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