Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR)

Beverly H. Brummett, Stephen H. Boyle, Ilene C. Siegler, Cynthia M. Kuhn, Allison Ashley-Koch, Charles R. Jonassaint, Stephan L Zuchner, Ann Collins, Redford B. Williams

Research output: Contribution to journalArticle

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Abstract

The short (s) variant of the serotonin transporter (5-HTT) gene linked functional polymorphic region (5-HTTLPR) is associated with depression. Stressful life events, gender, and race have been shown to moderate this association. We examined the relationship between 5-HTTLPR genotype and symptoms of depression in two samples. Study 1 = 288 participants from a study of caregiver stress; and Study 2 = 142 participants from a study examining psychosocial stressors, genetics, and health. Main effects of 5-HTTLPR on symptoms of depression were examined, along with moderation by stress (caregiving status or low childhood socioeconomic status (SES), gender, and race. The 5-HTTLPR x stress group x gender interaction was significant in both samples (P < 0.003, and P < 0.008, respectively). For females, the s allele, combined with caregiving stress (Study 1) or low childhood SES (Study 2), was associated with higher depression scores as compared to participants in the non-stressor group and those with the long (l) allele; whereas, in males, the l allele, combined with a stressor, was associated with higher depression scores as compared to those in the non-stressor group and those with the s allele. Findings from two independent samples suggest that the association of 5-HTTLPR with depression varies according to gender and stressful life events.

Original languageEnglish
Pages (from-to)34-43
Number of pages10
JournalBehavior Genetics
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2008

Fingerprint

Serotonin Plasma Membrane Transport Proteins
environmental stress
serotonin
transporters
gender
allele
Alleles
gene
alleles
life events
socioeconomic status
Genes
genes
childhood
Social Class
caregivers
sampling
Caregivers
genotype
Genotype

Keywords

  • 5-HTTLPR
  • Caregiving
  • Depressive Symptoms
  • Gender difference
  • Race
  • Socioeconomic Status

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Behavioral Neuroscience
  • Psychology(all)

Cite this

Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR). / Brummett, Beverly H.; Boyle, Stephen H.; Siegler, Ilene C.; Kuhn, Cynthia M.; Ashley-Koch, Allison; Jonassaint, Charles R.; Zuchner, Stephan L; Collins, Ann; Williams, Redford B.

In: Behavior Genetics, Vol. 38, No. 1, 01.01.2008, p. 34-43.

Research output: Contribution to journalArticle

Brummett, Beverly H. ; Boyle, Stephen H. ; Siegler, Ilene C. ; Kuhn, Cynthia M. ; Ashley-Koch, Allison ; Jonassaint, Charles R. ; Zuchner, Stephan L ; Collins, Ann ; Williams, Redford B. / Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR). In: Behavior Genetics. 2008 ; Vol. 38, No. 1. pp. 34-43.
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