Effects of dry air and subsequent humidification on tracheal mucous velocity in dogs

J. A. Hirsch, J. L. Tokayer, M. J. Robinson, M. A. Sackner

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The impairment of mucociliary transport by dry air breathing and the restoration of function with subsequent humidification of inspired air were investigated in anesthetized dogs. Tracheal mucous velocity was measured by a cinebronchofiberscopic technique. The breathing of dry air through an uncuffed endotracheal tube produced almost complete cessation of the flow of tracheal mucus after 3 h. Subsequent breathing of air at 38°C with 100% relative humidity restored tracheal mucous velocity to control values by the end of an additional 3 h. Histologic examination of the trachea at the end of the 3 h dry air breathing period revealed focal areas of sloughing of the ciliated epithelium and submucosal inflammation. Although morphometry was not employed, the inflammatory changes appeared to have progressed during 3 h of breathing fully humidified air subsequent to the dry air breathing period. These findings were consistent with previous reports that the inflammatory response to injury of the tracheobronchial mucosa might be delayed and that the mucociliary transport system has a great deal of functional reserve. The authors found that an artificial heat and moisture exchanger placed on the proximal end of an endotracheal tube partially protects against the suppression of tracheal mucous velocity caused by dry air breathing.

Original languageEnglish
Pages (from-to)242-246
Number of pages5
JournalJournal of Applied Physiology
Volume39
Issue number2
StatePublished - Dec 1 1975
Externally publishedYes

Fingerprint

Air
Respiration
Dogs
Mucociliary Clearance
Mucus
Humidity
Trachea
Mucous Membrane
Epithelium
Hot Temperature
Inflammation
Wounds and Injuries

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Hirsch, J. A., Tokayer, J. L., Robinson, M. J., & Sackner, M. A. (1975). Effects of dry air and subsequent humidification on tracheal mucous velocity in dogs. Journal of Applied Physiology, 39(2), 242-246.

Effects of dry air and subsequent humidification on tracheal mucous velocity in dogs. / Hirsch, J. A.; Tokayer, J. L.; Robinson, M. J.; Sackner, M. A.

In: Journal of Applied Physiology, Vol. 39, No. 2, 01.12.1975, p. 242-246.

Research output: Contribution to journalArticle

Hirsch, JA, Tokayer, JL, Robinson, MJ & Sackner, MA 1975, 'Effects of dry air and subsequent humidification on tracheal mucous velocity in dogs', Journal of Applied Physiology, vol. 39, no. 2, pp. 242-246.
Hirsch JA, Tokayer JL, Robinson MJ, Sackner MA. Effects of dry air and subsequent humidification on tracheal mucous velocity in dogs. Journal of Applied Physiology. 1975 Dec 1;39(2):242-246.
Hirsch, J. A. ; Tokayer, J. L. ; Robinson, M. J. ; Sackner, M. A. / Effects of dry air and subsequent humidification on tracheal mucous velocity in dogs. In: Journal of Applied Physiology. 1975 ; Vol. 39, No. 2. pp. 242-246.
@article{f12e412e590a444a8fd44840827a6abe,
title = "Effects of dry air and subsequent humidification on tracheal mucous velocity in dogs",
abstract = "The impairment of mucociliary transport by dry air breathing and the restoration of function with subsequent humidification of inspired air were investigated in anesthetized dogs. Tracheal mucous velocity was measured by a cinebronchofiberscopic technique. The breathing of dry air through an uncuffed endotracheal tube produced almost complete cessation of the flow of tracheal mucus after 3 h. Subsequent breathing of air at 38°C with 100{\%} relative humidity restored tracheal mucous velocity to control values by the end of an additional 3 h. Histologic examination of the trachea at the end of the 3 h dry air breathing period revealed focal areas of sloughing of the ciliated epithelium and submucosal inflammation. Although morphometry was not employed, the inflammatory changes appeared to have progressed during 3 h of breathing fully humidified air subsequent to the dry air breathing period. These findings were consistent with previous reports that the inflammatory response to injury of the tracheobronchial mucosa might be delayed and that the mucociliary transport system has a great deal of functional reserve. The authors found that an artificial heat and moisture exchanger placed on the proximal end of an endotracheal tube partially protects against the suppression of tracheal mucous velocity caused by dry air breathing.",
author = "Hirsch, {J. A.} and Tokayer, {J. L.} and Robinson, {M. J.} and Sackner, {M. A.}",
year = "1975",
month = "12",
day = "1",
language = "English",
volume = "39",
pages = "242--246",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "2",

}

TY - JOUR

T1 - Effects of dry air and subsequent humidification on tracheal mucous velocity in dogs

AU - Hirsch, J. A.

AU - Tokayer, J. L.

AU - Robinson, M. J.

AU - Sackner, M. A.

PY - 1975/12/1

Y1 - 1975/12/1

N2 - The impairment of mucociliary transport by dry air breathing and the restoration of function with subsequent humidification of inspired air were investigated in anesthetized dogs. Tracheal mucous velocity was measured by a cinebronchofiberscopic technique. The breathing of dry air through an uncuffed endotracheal tube produced almost complete cessation of the flow of tracheal mucus after 3 h. Subsequent breathing of air at 38°C with 100% relative humidity restored tracheal mucous velocity to control values by the end of an additional 3 h. Histologic examination of the trachea at the end of the 3 h dry air breathing period revealed focal areas of sloughing of the ciliated epithelium and submucosal inflammation. Although morphometry was not employed, the inflammatory changes appeared to have progressed during 3 h of breathing fully humidified air subsequent to the dry air breathing period. These findings were consistent with previous reports that the inflammatory response to injury of the tracheobronchial mucosa might be delayed and that the mucociliary transport system has a great deal of functional reserve. The authors found that an artificial heat and moisture exchanger placed on the proximal end of an endotracheal tube partially protects against the suppression of tracheal mucous velocity caused by dry air breathing.

AB - The impairment of mucociliary transport by dry air breathing and the restoration of function with subsequent humidification of inspired air were investigated in anesthetized dogs. Tracheal mucous velocity was measured by a cinebronchofiberscopic technique. The breathing of dry air through an uncuffed endotracheal tube produced almost complete cessation of the flow of tracheal mucus after 3 h. Subsequent breathing of air at 38°C with 100% relative humidity restored tracheal mucous velocity to control values by the end of an additional 3 h. Histologic examination of the trachea at the end of the 3 h dry air breathing period revealed focal areas of sloughing of the ciliated epithelium and submucosal inflammation. Although morphometry was not employed, the inflammatory changes appeared to have progressed during 3 h of breathing fully humidified air subsequent to the dry air breathing period. These findings were consistent with previous reports that the inflammatory response to injury of the tracheobronchial mucosa might be delayed and that the mucociliary transport system has a great deal of functional reserve. The authors found that an artificial heat and moisture exchanger placed on the proximal end of an endotracheal tube partially protects against the suppression of tracheal mucous velocity caused by dry air breathing.

UR - http://www.scopus.com/inward/record.url?scp=0016815987&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016815987&partnerID=8YFLogxK

M3 - Article

VL - 39

SP - 242

EP - 246

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 2

ER -