Effects of diethyl ether and nitrous oxide on functionally skinned myocardial cells of rabbits

J. Y. Su, W. G.L. Kerrick, S. A. Hill

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Abstract

Diethyl ether and nitrous oxide at clinical concentrations were shown to slightly but significantly decrease the maximal Ca2+-activated tension. Measured caffeine-induced tension transients of functionally skinned papillary muscle fibers indicate that diethyl ether inhibited the CA2+ release mechanism in the sarcoplasmic reticulum and increased the amount of Ca2+ sequestered into the sarcoplasmic reticulum. The overall effect of continuously exposing the fibers to 6% or higher concentrations of diethyl ether was to depress the amount of Ca2+ released from the sarcoplasmic reticulum. We therefore conclude that the mechanisms of myocardial depression by diethyl ether may be due in part to an inhibition of the Ca2+ release mechanism of the sarcoplasmic reticulum and in part to a decrease in the maximal Ca2+-activated tension. Nitrous oxide-induced myocardial depression could only partly be due to a decrease in the maximal Ca2+-activated tension.

Original languageEnglish (US)
Pages (from-to)451-456
Number of pages6
JournalAnesthesia and analgesia
Volume63
Issue number4
StatePublished - Jan 1 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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