Effects of dietary inorganic trivalent chromium (Cr3+) on the development of glucose homeostasis in rats

P. R. Flatt, L. Juntti-Berggren, P. O. Berggren, B. J. Gould, S. K. Swanston-Flatt

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Inorganic chromium (Cr3+) is classified as an essential trace element on the basis of a small dietary requirement for the maintenance of efficient glucose homeostasis. The present study has carefully scrutinised this claim by examining food intake, body weight gain, glycosylated haemoglobins, plasma glucose and insulin concentrations, glucose tolerance and insulin sensitivity in two groups of Wistar rats fed either a Cr3+-deficient (0.03 mg/kg) or Cr3+-containing (1 mg/kg) diet for 32 days from weaning at 3 weeks. At 53 days of age, control rats weighed 183 ± 7 g (body weight gain 155 ± 6 g, mean ± SEM) and consumed 17 ± 1 g diet/rat/day. Glycosylated haemoglobins, plasma glucose and plasma insulin were 2.5 ± 1%, 6.4 ± 0.3 mmol/l and 1.2 ± 0.3 ng/ml, respectively. Compared with control rats, the rats fed the Cr3+-deficient diet consumed the same total amount of diet and exhibited up to a maximum 40% decrease in the chromium content of selected tissues at 53 days of age. At no time during the study did food intake, body weight, glycosylated haemoglobins or plasma concentrations of glucose and insulin differ between the two groups of rats. Furthermore, body weight gain and both glucose tolerance and insulin sensitivity were identical at 50-53 days of age. These results cast doubt on the significance of dietary trivalent chromium for the maintenance of glucose homeostasis in healthy animals.

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalDiabete et Metabolisme
Volume15
Issue number2
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Chromium
Homeostasis
Glucose
Glycosylated Hemoglobin A
Body Weight
Diet
Weight Gain
Insulin
Insulin Resistance
Eating
Maintenance
Nutritional Requirements
Trace Elements
Weaning
Wistar Rats

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Flatt, P. R., Juntti-Berggren, L., Berggren, P. O., Gould, B. J., & Swanston-Flatt, S. K. (1989). Effects of dietary inorganic trivalent chromium (Cr3+) on the development of glucose homeostasis in rats. Diabete et Metabolisme, 15(2), 93-97.

Effects of dietary inorganic trivalent chromium (Cr3+) on the development of glucose homeostasis in rats. / Flatt, P. R.; Juntti-Berggren, L.; Berggren, P. O.; Gould, B. J.; Swanston-Flatt, S. K.

In: Diabete et Metabolisme, Vol. 15, No. 2, 01.01.1989, p. 93-97.

Research output: Contribution to journalArticle

Flatt, PR, Juntti-Berggren, L, Berggren, PO, Gould, BJ & Swanston-Flatt, SK 1989, 'Effects of dietary inorganic trivalent chromium (Cr3+) on the development of glucose homeostasis in rats', Diabete et Metabolisme, vol. 15, no. 2, pp. 93-97.
Flatt PR, Juntti-Berggren L, Berggren PO, Gould BJ, Swanston-Flatt SK. Effects of dietary inorganic trivalent chromium (Cr3+) on the development of glucose homeostasis in rats. Diabete et Metabolisme. 1989 Jan 1;15(2):93-97.
Flatt, P. R. ; Juntti-Berggren, L. ; Berggren, P. O. ; Gould, B. J. ; Swanston-Flatt, S. K. / Effects of dietary inorganic trivalent chromium (Cr3+) on the development of glucose homeostasis in rats. In: Diabete et Metabolisme. 1989 ; Vol. 15, No. 2. pp. 93-97.
@article{9f3e5d47480c4734ac14c941469ca0a4,
title = "Effects of dietary inorganic trivalent chromium (Cr3+) on the development of glucose homeostasis in rats",
abstract = "Inorganic chromium (Cr3+) is classified as an essential trace element on the basis of a small dietary requirement for the maintenance of efficient glucose homeostasis. The present study has carefully scrutinised this claim by examining food intake, body weight gain, glycosylated haemoglobins, plasma glucose and insulin concentrations, glucose tolerance and insulin sensitivity in two groups of Wistar rats fed either a Cr3+-deficient (0.03 mg/kg) or Cr3+-containing (1 mg/kg) diet for 32 days from weaning at 3 weeks. At 53 days of age, control rats weighed 183 ± 7 g (body weight gain 155 ± 6 g, mean ± SEM) and consumed 17 ± 1 g diet/rat/day. Glycosylated haemoglobins, plasma glucose and plasma insulin were 2.5 ± 1{\%}, 6.4 ± 0.3 mmol/l and 1.2 ± 0.3 ng/ml, respectively. Compared with control rats, the rats fed the Cr3+-deficient diet consumed the same total amount of diet and exhibited up to a maximum 40{\%} decrease in the chromium content of selected tissues at 53 days of age. At no time during the study did food intake, body weight, glycosylated haemoglobins or plasma concentrations of glucose and insulin differ between the two groups of rats. Furthermore, body weight gain and both glucose tolerance and insulin sensitivity were identical at 50-53 days of age. These results cast doubt on the significance of dietary trivalent chromium for the maintenance of glucose homeostasis in healthy animals.",
author = "Flatt, {P. R.} and L. Juntti-Berggren and Berggren, {P. O.} and Gould, {B. J.} and Swanston-Flatt, {S. K.}",
year = "1989",
month = "1",
day = "1",
language = "English",
volume = "15",
pages = "93--97",
journal = "Diabetes and Metabolism",
issn = "1262-3636",
publisher = "Elsevier Masson",
number = "2",

}

TY - JOUR

T1 - Effects of dietary inorganic trivalent chromium (Cr3+) on the development of glucose homeostasis in rats

AU - Flatt, P. R.

AU - Juntti-Berggren, L.

AU - Berggren, P. O.

AU - Gould, B. J.

AU - Swanston-Flatt, S. K.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Inorganic chromium (Cr3+) is classified as an essential trace element on the basis of a small dietary requirement for the maintenance of efficient glucose homeostasis. The present study has carefully scrutinised this claim by examining food intake, body weight gain, glycosylated haemoglobins, plasma glucose and insulin concentrations, glucose tolerance and insulin sensitivity in two groups of Wistar rats fed either a Cr3+-deficient (0.03 mg/kg) or Cr3+-containing (1 mg/kg) diet for 32 days from weaning at 3 weeks. At 53 days of age, control rats weighed 183 ± 7 g (body weight gain 155 ± 6 g, mean ± SEM) and consumed 17 ± 1 g diet/rat/day. Glycosylated haemoglobins, plasma glucose and plasma insulin were 2.5 ± 1%, 6.4 ± 0.3 mmol/l and 1.2 ± 0.3 ng/ml, respectively. Compared with control rats, the rats fed the Cr3+-deficient diet consumed the same total amount of diet and exhibited up to a maximum 40% decrease in the chromium content of selected tissues at 53 days of age. At no time during the study did food intake, body weight, glycosylated haemoglobins or plasma concentrations of glucose and insulin differ between the two groups of rats. Furthermore, body weight gain and both glucose tolerance and insulin sensitivity were identical at 50-53 days of age. These results cast doubt on the significance of dietary trivalent chromium for the maintenance of glucose homeostasis in healthy animals.

AB - Inorganic chromium (Cr3+) is classified as an essential trace element on the basis of a small dietary requirement for the maintenance of efficient glucose homeostasis. The present study has carefully scrutinised this claim by examining food intake, body weight gain, glycosylated haemoglobins, plasma glucose and insulin concentrations, glucose tolerance and insulin sensitivity in two groups of Wistar rats fed either a Cr3+-deficient (0.03 mg/kg) or Cr3+-containing (1 mg/kg) diet for 32 days from weaning at 3 weeks. At 53 days of age, control rats weighed 183 ± 7 g (body weight gain 155 ± 6 g, mean ± SEM) and consumed 17 ± 1 g diet/rat/day. Glycosylated haemoglobins, plasma glucose and plasma insulin were 2.5 ± 1%, 6.4 ± 0.3 mmol/l and 1.2 ± 0.3 ng/ml, respectively. Compared with control rats, the rats fed the Cr3+-deficient diet consumed the same total amount of diet and exhibited up to a maximum 40% decrease in the chromium content of selected tissues at 53 days of age. At no time during the study did food intake, body weight, glycosylated haemoglobins or plasma concentrations of glucose and insulin differ between the two groups of rats. Furthermore, body weight gain and both glucose tolerance and insulin sensitivity were identical at 50-53 days of age. These results cast doubt on the significance of dietary trivalent chromium for the maintenance of glucose homeostasis in healthy animals.

UR - http://www.scopus.com/inward/record.url?scp=0024403131&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024403131&partnerID=8YFLogxK

M3 - Article

C2 - 2661282

AN - SCOPUS:0024403131

VL - 15

SP - 93

EP - 97

JO - Diabetes and Metabolism

JF - Diabetes and Metabolism

SN - 1262-3636

IS - 2

ER -