Effects of dexamethasone on retinal and choroidal blood flow during normoxia and hyperoxia in newborn piglets

T. A. Stiris, D. Blanco, R. Codoceo, D. Lasa, C. Suguihara, Eduardo Bancalari, J. Quero

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Our purpose was to study the effect of dexamethasone (DEX) on choroidal (ChBF) and retinal blood flow (RBF) during normoxia and hyperoxia. Eighteen spontaneously breathing newborn piglets were examined. ChBF and RBF were measured using radiolabeled microspheres while the piglets were in normoxia before (RA1) and 45 min after either saline or DEX (2 mg/kg) infusion (RA2), and after 90 min of hyperoxia (O2) (Pao2 40-60 kPa). Vitreous prostanoids (prostaglandins F(1α) and E2 and thromboxane B2) and leukotrienes (leukotriene B4) measurements were obtained during normoxia after either placebo or DEX infusion in an additional 22 piglets. Vitreous prostanoids were also studied after 90 min of hyperoxia. We found that RBF increased significantly after DEX infusion (p < 0.02). There was no change in RBF from RA1 to RA2, before and after saline infusion. RBF decreased significantly during hyperoxia in both groups (p < 0.03). ChBF did not change significantly between RA1 and RA2 in any of the groups. ChBF decreased significantly during hyperoxia in both groups (p < 0.03). Vitreous prostanoids and leukotrienes were reduced significantly after DEX infusion (p < 0.05). Prostanoids were similar in the two groups during hyperoxia. We concluded that DEX increases RBF significantly, but not ChBF. RBF and ChBF decreased in both groups during hyperoxia. Therefore, the metabolites of arachidonic acid do not seem to be involved as mediators of hyperoxic vasoconstriction.

Original languageEnglish
Pages (from-to)592-596
Number of pages5
JournalPediatric Research
Volume40
Issue number4
StatePublished - Oct 1 1996

Fingerprint

Hyperoxia
Dexamethasone
Prostaglandins
Leukotrienes
Thromboxane B2
Leukotriene B4
Prostaglandins F
Vasoconstriction
Microspheres
Dinoprostone
Arachidonic Acid
Respiration
Placebos

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Stiris, T. A., Blanco, D., Codoceo, R., Lasa, D., Suguihara, C., Bancalari, E., & Quero, J. (1996). Effects of dexamethasone on retinal and choroidal blood flow during normoxia and hyperoxia in newborn piglets. Pediatric Research, 40(4), 592-596.

Effects of dexamethasone on retinal and choroidal blood flow during normoxia and hyperoxia in newborn piglets. / Stiris, T. A.; Blanco, D.; Codoceo, R.; Lasa, D.; Suguihara, C.; Bancalari, Eduardo; Quero, J.

In: Pediatric Research, Vol. 40, No. 4, 01.10.1996, p. 592-596.

Research output: Contribution to journalArticle

Stiris, TA, Blanco, D, Codoceo, R, Lasa, D, Suguihara, C, Bancalari, E & Quero, J 1996, 'Effects of dexamethasone on retinal and choroidal blood flow during normoxia and hyperoxia in newborn piglets', Pediatric Research, vol. 40, no. 4, pp. 592-596.
Stiris, T. A. ; Blanco, D. ; Codoceo, R. ; Lasa, D. ; Suguihara, C. ; Bancalari, Eduardo ; Quero, J. / Effects of dexamethasone on retinal and choroidal blood flow during normoxia and hyperoxia in newborn piglets. In: Pediatric Research. 1996 ; Vol. 40, No. 4. pp. 592-596.
@article{33e634414a364a49b5f1ee750c210c97,
title = "Effects of dexamethasone on retinal and choroidal blood flow during normoxia and hyperoxia in newborn piglets",
abstract = "Our purpose was to study the effect of dexamethasone (DEX) on choroidal (ChBF) and retinal blood flow (RBF) during normoxia and hyperoxia. Eighteen spontaneously breathing newborn piglets were examined. ChBF and RBF were measured using radiolabeled microspheres while the piglets were in normoxia before (RA1) and 45 min after either saline or DEX (2 mg/kg) infusion (RA2), and after 90 min of hyperoxia (O2) (Pao2 40-60 kPa). Vitreous prostanoids (prostaglandins F(1α) and E2 and thromboxane B2) and leukotrienes (leukotriene B4) measurements were obtained during normoxia after either placebo or DEX infusion in an additional 22 piglets. Vitreous prostanoids were also studied after 90 min of hyperoxia. We found that RBF increased significantly after DEX infusion (p < 0.02). There was no change in RBF from RA1 to RA2, before and after saline infusion. RBF decreased significantly during hyperoxia in both groups (p < 0.03). ChBF did not change significantly between RA1 and RA2 in any of the groups. ChBF decreased significantly during hyperoxia in both groups (p < 0.03). Vitreous prostanoids and leukotrienes were reduced significantly after DEX infusion (p < 0.05). Prostanoids were similar in the two groups during hyperoxia. We concluded that DEX increases RBF significantly, but not ChBF. RBF and ChBF decreased in both groups during hyperoxia. Therefore, the metabolites of arachidonic acid do not seem to be involved as mediators of hyperoxic vasoconstriction.",
author = "Stiris, {T. A.} and D. Blanco and R. Codoceo and D. Lasa and C. Suguihara and Eduardo Bancalari and J. Quero",
year = "1996",
month = "10",
day = "1",
language = "English",
volume = "40",
pages = "592--596",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Effects of dexamethasone on retinal and choroidal blood flow during normoxia and hyperoxia in newborn piglets

AU - Stiris, T. A.

AU - Blanco, D.

AU - Codoceo, R.

AU - Lasa, D.

AU - Suguihara, C.

AU - Bancalari, Eduardo

AU - Quero, J.

PY - 1996/10/1

Y1 - 1996/10/1

N2 - Our purpose was to study the effect of dexamethasone (DEX) on choroidal (ChBF) and retinal blood flow (RBF) during normoxia and hyperoxia. Eighteen spontaneously breathing newborn piglets were examined. ChBF and RBF were measured using radiolabeled microspheres while the piglets were in normoxia before (RA1) and 45 min after either saline or DEX (2 mg/kg) infusion (RA2), and after 90 min of hyperoxia (O2) (Pao2 40-60 kPa). Vitreous prostanoids (prostaglandins F(1α) and E2 and thromboxane B2) and leukotrienes (leukotriene B4) measurements were obtained during normoxia after either placebo or DEX infusion in an additional 22 piglets. Vitreous prostanoids were also studied after 90 min of hyperoxia. We found that RBF increased significantly after DEX infusion (p < 0.02). There was no change in RBF from RA1 to RA2, before and after saline infusion. RBF decreased significantly during hyperoxia in both groups (p < 0.03). ChBF did not change significantly between RA1 and RA2 in any of the groups. ChBF decreased significantly during hyperoxia in both groups (p < 0.03). Vitreous prostanoids and leukotrienes were reduced significantly after DEX infusion (p < 0.05). Prostanoids were similar in the two groups during hyperoxia. We concluded that DEX increases RBF significantly, but not ChBF. RBF and ChBF decreased in both groups during hyperoxia. Therefore, the metabolites of arachidonic acid do not seem to be involved as mediators of hyperoxic vasoconstriction.

AB - Our purpose was to study the effect of dexamethasone (DEX) on choroidal (ChBF) and retinal blood flow (RBF) during normoxia and hyperoxia. Eighteen spontaneously breathing newborn piglets were examined. ChBF and RBF were measured using radiolabeled microspheres while the piglets were in normoxia before (RA1) and 45 min after either saline or DEX (2 mg/kg) infusion (RA2), and after 90 min of hyperoxia (O2) (Pao2 40-60 kPa). Vitreous prostanoids (prostaglandins F(1α) and E2 and thromboxane B2) and leukotrienes (leukotriene B4) measurements were obtained during normoxia after either placebo or DEX infusion in an additional 22 piglets. Vitreous prostanoids were also studied after 90 min of hyperoxia. We found that RBF increased significantly after DEX infusion (p < 0.02). There was no change in RBF from RA1 to RA2, before and after saline infusion. RBF decreased significantly during hyperoxia in both groups (p < 0.03). ChBF did not change significantly between RA1 and RA2 in any of the groups. ChBF decreased significantly during hyperoxia in both groups (p < 0.03). Vitreous prostanoids and leukotrienes were reduced significantly after DEX infusion (p < 0.05). Prostanoids were similar in the two groups during hyperoxia. We concluded that DEX increases RBF significantly, but not ChBF. RBF and ChBF decreased in both groups during hyperoxia. Therefore, the metabolites of arachidonic acid do not seem to be involved as mediators of hyperoxic vasoconstriction.

UR - http://www.scopus.com/inward/record.url?scp=0029785820&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029785820&partnerID=8YFLogxK

M3 - Article

VL - 40

SP - 592

EP - 596

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 4

ER -