Effects of dapsone on passive Arthus reaction and chemotaxis and phagocytosis of polymorphonuclear leukocytes

Thomas Ruzicka, Anette Bauer, Stefan Glück, Monika Born

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The effects of dapsone (diaminodiphenyl sulfone) on the polymorphonuclear leukocyte (PMNL) function and on the elicitation of the passive Arthus reaction were investigated in rabbits and guinea-pigs. NBT-reduction was markedly enhanced in PMNL of animal receiving 5 mg dapsone/kg for 3 days, whereas chemotaxis and phagocytosis were not influenced. Passive Arthus reaction was clearly suppressed by the same treatment regimen. 2 mg/kg of the drug had no effect on the parameters examined.

Original languageEnglish (US)
Pages (from-to)347-351
Number of pages5
JournalArchives of Dermatological Research
Volume270
Issue number3
DOIs
StatePublished - May 1 1981

Keywords

  • Arthus Reaction
  • Dapsone
  • PMNL Function

ASJC Scopus subject areas

  • Dermatology

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