Effects of dapsone on passive Arthus reaction and chemotaxis and phagocytosis of polymorphonuclear leukocytes

Thomas Ruzicka, Anette Bauer, Stefan Glück, Monika Born

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The effects of dapsone (diaminodiphenyl sulfone) on the polymorphonuclear leukocyte (PMNL) function and on the elicitation of the passive Arthus reaction were investigated in rabbits and guinea-pigs. NBT-reduction was markedly enhanced in PMNL of animal receiving 5 mg dapsone/kg for 3 days, whereas chemotaxis and phagocytosis were not influenced. Passive Arthus reaction was clearly suppressed by the same treatment regimen. 2 mg/kg of the drug had no effect on the parameters examined.

Original languageEnglish (US)
Pages (from-to)347-351
Number of pages5
JournalArchives of Dermatological Research
Issue number3
StatePublished - May 1 1981



  • Arthus Reaction
  • Dapsone
  • PMNL Function

ASJC Scopus subject areas

  • Dermatology

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