Effects of Danazol on gonadotropin secretion after ovariectomy in rats

J. A. Vilchez-Martinez, E. Pedroza, A. Arimura, Andrew V Schally

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effects of Danazol on the elevated levels of serum gonadotropins and on the pituitary response to LH-RH in ovariectomized rats pretreated or not pretreated with estradiol and progesterone, were studied. Danazol depresses significantly the elevated serum levels of LH, but not those of FSH. The LH and FSH response to LH-RH in ovariectomized rats was increased by Danazol. This compound partially modified the inhibitory action of estradiol and progesterone on the serum levels of LH and nullified the depression of FSH. The results indicate that the effects of Danazol on the gonadotropic function of the pituitary depend on the functional state of the gland and/or the duration of the treatment.

Original languageEnglish
Pages (from-to)283-290
Number of pages8
JournalContraception
Volume17
Issue number3
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

Fingerprint

Danazol
Ovariectomy
Gonadotropins
Gonadotropin-Releasing Hormone
Progesterone
Estradiol
Serum
Pituitary Gonadotropins

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Effects of Danazol on gonadotropin secretion after ovariectomy in rats. / Vilchez-Martinez, J. A.; Pedroza, E.; Arimura, A.; Schally, Andrew V.

In: Contraception, Vol. 17, No. 3, 01.01.1978, p. 283-290.

Research output: Contribution to journalArticle

Vilchez-Martinez, J. A. ; Pedroza, E. ; Arimura, A. ; Schally, Andrew V. / Effects of Danazol on gonadotropin secretion after ovariectomy in rats. In: Contraception. 1978 ; Vol. 17, No. 3. pp. 283-290.
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