Effects of Danazol on gonadotropin secretion after ovariectomy in rats

J. A. Vilchez-Martinez, E. Pedroza, A. Arimura, A. V. Schally

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The effects of Danazol on the elevated levels of serum gonadotropins and on the pituitary response to LH-RH in ovariectomized rats pretreated or not pretreated with estradiol and progesterone, were studied. Danazol depresses significantly the elevated serum levels of LH, but not those of FSH. The LH and FSH response to LH-RH in ovariectomized rats was increased by Danazol. This compound partially modified the inhibitory action of estradiol and progesterone on the serum levels of LH and nullified the depression of FSH. The results indicate that the effects of Danazol on the gonadotropic function of the pituitary depend on the functional state of the gland and/or the duration of the treatment.

Original languageEnglish (US)
Pages (from-to)283-290
Number of pages8
JournalContraception
Volume17
Issue number3
DOIs
StatePublished - Mar 1978
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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