Effects of Danazol on endometrial DNA synthesis in rats

Satoe Suzuki, Shinobu Sakamoto, Hideki Kudo, Shuji Sassa, Yoshie Sugiura, Katsuhiko Kuwa, Noriyuki Kasahara, Takao Mori, Hiroshi Nagasawa

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Abstract

The suppressive effects of Danazol, an isoxazol derivative of the synthetic steroid 17 α-ethinyltestosterone, on endometrial DNA synthesis were investigated in rats by immunohistochemistry with bromodeoxyuridine (BrdU) and DNA-synthesizing enzyme assays. Rats treated with Danazol for 14 days at 17-19 weeks of age showed a decrease of plasma gonadotropins associated with ovarian hypofunction, persistent diestrus, and a smaller number of corpora lutea in ovary, resulting in no BrdU-immunoreactive (S-phase) cells in endometrial epithelium and lower activity of thymidine kinase in the uterus compared with control.

Original languageEnglish (US)
Pages (from-to)551-553
Number of pages3
JournalSteroids
Volume58
Issue number11
DOIs
StatePublished - 1993
Externally publishedYes

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Keywords

  • Danazol
  • DNA synthesis
  • endometrium

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Molecular Biology

Cite this

Suzuki, S., Sakamoto, S., Kudo, H., Sassa, S., Sugiura, Y., Kuwa, K., Kasahara, N., Mori, T., & Nagasawa, H. (1993). Effects of Danazol on endometrial DNA synthesis in rats. Steroids, 58(11), 551-553. https://doi.org/10.1016/0039-128X(93)90034-K