Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of virology|
|State||Published - Oct 1 2002|
ASJC Scopus subject areas
- Insect Science