Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) gag CTL epitope on the course of SIVmac239 infection

Todd M. Allen, Peicheng Jing, Briana Calore, Helen Horton, David H. O'Connor, Tomas Hanke, Marian Piekarczyk, Richard Ruddersdorf, Bianca R. Mothé, Carol Emerson, Nancy Wilson, Jeffrey D. Lifson, Igor M. Belyakov, Jay A. Berzofsky, Chenxi Wang, David B. Allison, David C. Montefiori, Ronald Charles Desrosiers, Steven Wolinsky, Kevin J. Kunstman & 4 others John D. Altman, Alessandro Sette, Andrew J. McMichael, David Watkins

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.

Original languageEnglish
Pages (from-to)10507-10511
Number of pages5
JournalJournal of Virology
Volume76
Issue number20
DOIs
StatePublished - Oct 1 2002
Externally publishedYes

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Simian immunodeficiency virus
Simian Immunodeficiency Virus
cytotoxic T-lymphocytes
T-Lymphocyte Epitopes
Cytotoxic T-Lymphocytes
epitopes
Vaccines
Infection
infection
vaccines
Immunodominant Epitopes
Human immunodeficiency virus
Macaca
Virus Replication
virus replication
immune response
HIV
testing

ASJC Scopus subject areas

  • Immunology

Cite this

Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) gag CTL epitope on the course of SIVmac239 infection. / Allen, Todd M.; Jing, Peicheng; Calore, Briana; Horton, Helen; O'Connor, David H.; Hanke, Tomas; Piekarczyk, Marian; Ruddersdorf, Richard; Mothé, Bianca R.; Emerson, Carol; Wilson, Nancy; Lifson, Jeffrey D.; Belyakov, Igor M.; Berzofsky, Jay A.; Wang, Chenxi; Allison, David B.; Montefiori, David C.; Desrosiers, Ronald Charles; Wolinsky, Steven; Kunstman, Kevin J.; Altman, John D.; Sette, Alessandro; McMichael, Andrew J.; Watkins, David.

In: Journal of Virology, Vol. 76, No. 20, 01.10.2002, p. 10507-10511.

Research output: Contribution to journalArticle

Allen, TM, Jing, P, Calore, B, Horton, H, O'Connor, DH, Hanke, T, Piekarczyk, M, Ruddersdorf, R, Mothé, BR, Emerson, C, Wilson, N, Lifson, JD, Belyakov, IM, Berzofsky, JA, Wang, C, Allison, DB, Montefiori, DC, Desrosiers, RC, Wolinsky, S, Kunstman, KJ, Altman, JD, Sette, A, McMichael, AJ & Watkins, D 2002, 'Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) gag CTL epitope on the course of SIVmac239 infection', Journal of Virology, vol. 76, no. 20, pp. 10507-10511. https://doi.org/10.1128/JVI.76.20.10507-10511.2002
Allen, Todd M. ; Jing, Peicheng ; Calore, Briana ; Horton, Helen ; O'Connor, David H. ; Hanke, Tomas ; Piekarczyk, Marian ; Ruddersdorf, Richard ; Mothé, Bianca R. ; Emerson, Carol ; Wilson, Nancy ; Lifson, Jeffrey D. ; Belyakov, Igor M. ; Berzofsky, Jay A. ; Wang, Chenxi ; Allison, David B. ; Montefiori, David C. ; Desrosiers, Ronald Charles ; Wolinsky, Steven ; Kunstman, Kevin J. ; Altman, John D. ; Sette, Alessandro ; McMichael, Andrew J. ; Watkins, David. / Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) gag CTL epitope on the course of SIVmac239 infection. In: Journal of Virology. 2002 ; Vol. 76, No. 20. pp. 10507-10511.
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