Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) gag CTL epitope on the course of SIVmac239 infection

Todd M. Allen, Peicheng Jing, Briana Calore, Helen Horton, David H. O'Connor, Tomas Hanke, Marian Piekarczyk, Richard Ruddersdorf, Bianca R. Mothé, Carol Emerson, Nancy Wilson, Jeffrey D. Lifson, Igor M. Belyakov, Jay A. Berzofsky, Chenxi Wang, David B. Allison, David C. Montefiori, Ronald C. Desrosiers, Steven Wolinsky, Kevin J. KunstmanJohn D. Altman, Alessandro Sette, Andrew J. McMichael, David I. Watkins

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.

Original languageEnglish (US)
Pages (from-to)10507-10511
Number of pages5
JournalJournal of virology
Volume76
Issue number20
DOIs
StatePublished - Oct 1 2002

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Allen, T. M., Jing, P., Calore, B., Horton, H., O'Connor, D. H., Hanke, T., Piekarczyk, M., Ruddersdorf, R., Mothé, B. R., Emerson, C., Wilson, N., Lifson, J. D., Belyakov, I. M., Berzofsky, J. A., Wang, C., Allison, D. B., Montefiori, D. C., Desrosiers, R. C., Wolinsky, S., ... Watkins, D. I. (2002). Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) gag CTL epitope on the course of SIVmac239 infection. Journal of virology, 76(20), 10507-10511. https://doi.org/10.1128/JVI.76.20.10507-10511.2002