Effects of CRF-like heptapeptide on catecholamine disappearance and serotonin accumulation in different brain areas of rats

Gyula Telegdy, Mátyás Fekete, David H. Coy, Andrew V. Schally

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The effects of intracerebroventricular administration of 1.0 ug of Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH /DC-9-39/ on the α-methyl-p-tyrosine /α-MPT/ -induced catecholamine disappearance and pargyline-induced serotonin accumulation in the hypothalamus, mesencephalon, septum, amygdala, cortex and striatum were studied. The dopamine disappearance was reduced in the hypothalamus and striatum, while it was increased in the septum. The serotonin accumulation was decreased in the hypothalamus, amygdala and cortex, but increased in the septum. The data indicate that this heptapeptide is able to modify the activities of the brain catecholaminergic and serotoninergic systems.

Original languageEnglish (US)
Pages (from-to)203-210
Number of pages8
JournalNeuropeptides
Volume2
Issue number3-4
DOIs
StatePublished - Mar 1982
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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