Effects of cold dry air nasal stimulation on airway mucosal blood flow in humans

Charles Le Merre, J. Isber, Alejandro D. Chediak, Adam Wanner

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Several studies have demonstrated that nasal challenges can induce reflex responses in the respiratory system. Some authors have described bronchoconstriction and modification of the pattern of breathing following nasal challenges by irritants and cold air. We propose to determine the effect of nasal stimulation with cold dry air on airway mucosal blood flow (Q aw) in the proximal tracheal bronchial tree of healthy humans. Nine healthy subjects participated in the study. Baseline measurement Qaw, nasal airway resistance (NAR) and airway caliber by specific airways conductance (SGaw) were followed by nasal challenge with cold dry air. Qaw, NAR and Sgaw were determined after the challenge. In those subjects in which a significant decline in Qaw was recorded the protocol was repeated after pretreatment with nasal anesthesia using topical lidocaine. Cold dry air challenge produced a significant decrease in mean Qaw for the nine subjects and this response was abolished by pretreatment with nasal anesthesia using topical lidocaine. There was no significant change in Sgaw and NAR after the challenge and topical lidocaine anesthesia. Our data indicates that nasal stimulation with cold dry air leads to a reduction in Qaw and that this effect may be mediated by a nasal reflex.

Original languageEnglish
Pages (from-to)327-329
Number of pages3
JournalArchives of Physiology and Biochemistry
Volume111
Issue number4
DOIs
StatePublished - Oct 1 2003

Fingerprint

Nose
Blood
Air
Lidocaine
Airway Resistance
Respiratory system
Anesthesia
Irritants
Reflex
Bronchoconstriction
Respiratory System
Healthy Volunteers
Respiration

Keywords

  • Airway blood flow
  • Cold air
  • Nasal bronchial reflexes
  • Nose

ASJC Scopus subject areas

  • Physiology
  • Biochemistry

Cite this

Effects of cold dry air nasal stimulation on airway mucosal blood flow in humans. / Le Merre, Charles; Isber, J.; Chediak, Alejandro D.; Wanner, Adam.

In: Archives of Physiology and Biochemistry, Vol. 111, No. 4, 01.10.2003, p. 327-329.

Research output: Contribution to journalArticle

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