Effects of clonidine and yohimbine, alone and in combination with morphine, on supraspinal analgesia

Sari E Izenwasser, C. Kornetsky

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Morphine raised the threshold for escape from aversive electrical stimulation, delivered to the mesencephalic reticular formation. Clonidine, given alone, had no effect; however, when administered with morphine it blocked the analgesic effect of morphine. Conversely, clonidine, but not morphine, increased the latency to respond to the aversive stimulation, suggesting that clonidine may not have analgesic properties but may merely impair the ability of the animal to respond to the nociceptive stimulation. Yohimbine produced hyperalgesia and also blocked the effect of morphine. These findings are similar to those seen with dopamine agonists and may be related to the effects of yohimbine on the release of dopamine.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalNeuropharmacology
Volume29
Issue number1
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Yohimbine
Clonidine
Analgesia
Morphine
Analgesics
Hyperalgesia
Dopamine Agonists
Electric Stimulation
Dopamine

Keywords

  • analgesia
  • clonidine
  • morphine
  • norepinephrine
  • yohimbine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

Effects of clonidine and yohimbine, alone and in combination with morphine, on supraspinal analgesia. / Izenwasser, Sari E; Kornetsky, C.

In: Neuropharmacology, Vol. 29, No. 1, 01.01.1990, p. 25-29.

Research output: Contribution to journalArticle

@article{53bee124c7274974a77ba5f89d9eac05,
title = "Effects of clonidine and yohimbine, alone and in combination with morphine, on supraspinal analgesia",
abstract = "Morphine raised the threshold for escape from aversive electrical stimulation, delivered to the mesencephalic reticular formation. Clonidine, given alone, had no effect; however, when administered with morphine it blocked the analgesic effect of morphine. Conversely, clonidine, but not morphine, increased the latency to respond to the aversive stimulation, suggesting that clonidine may not have analgesic properties but may merely impair the ability of the animal to respond to the nociceptive stimulation. Yohimbine produced hyperalgesia and also blocked the effect of morphine. These findings are similar to those seen with dopamine agonists and may be related to the effects of yohimbine on the release of dopamine.",
keywords = "analgesia, clonidine, morphine, norepinephrine, yohimbine",
author = "Izenwasser, {Sari E} and C. Kornetsky",
year = "1990",
month = "1",
day = "1",
doi = "10.1016/0028-3908(90)90079-7",
language = "English",
volume = "29",
pages = "25--29",
journal = "Neuropharmacology",
issn = "0028-3908",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Effects of clonidine and yohimbine, alone and in combination with morphine, on supraspinal analgesia

AU - Izenwasser, Sari E

AU - Kornetsky, C.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Morphine raised the threshold for escape from aversive electrical stimulation, delivered to the mesencephalic reticular formation. Clonidine, given alone, had no effect; however, when administered with morphine it blocked the analgesic effect of morphine. Conversely, clonidine, but not morphine, increased the latency to respond to the aversive stimulation, suggesting that clonidine may not have analgesic properties but may merely impair the ability of the animal to respond to the nociceptive stimulation. Yohimbine produced hyperalgesia and also blocked the effect of morphine. These findings are similar to those seen with dopamine agonists and may be related to the effects of yohimbine on the release of dopamine.

AB - Morphine raised the threshold for escape from aversive electrical stimulation, delivered to the mesencephalic reticular formation. Clonidine, given alone, had no effect; however, when administered with morphine it blocked the analgesic effect of morphine. Conversely, clonidine, but not morphine, increased the latency to respond to the aversive stimulation, suggesting that clonidine may not have analgesic properties but may merely impair the ability of the animal to respond to the nociceptive stimulation. Yohimbine produced hyperalgesia and also blocked the effect of morphine. These findings are similar to those seen with dopamine agonists and may be related to the effects of yohimbine on the release of dopamine.

KW - analgesia

KW - clonidine

KW - morphine

KW - norepinephrine

KW - yohimbine

UR - http://www.scopus.com/inward/record.url?scp=0025091863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025091863&partnerID=8YFLogxK

U2 - 10.1016/0028-3908(90)90079-7

DO - 10.1016/0028-3908(90)90079-7

M3 - Article

C2 - 2304613

AN - SCOPUS:0025091863

VL - 29

SP - 25

EP - 29

JO - Neuropharmacology

JF - Neuropharmacology

SN - 0028-3908

IS - 1

ER -