Effects of clonidine and yohimbine, alone and in combination with morphine, on supraspinal analgesia

S. Izenwasser, C. Kornetsky

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Morphine raised the threshold for escape from aversive electrical stimulation, delivered to the mesencephalic reticular formation. Clonidine, given alone, had no effect; however, when administered with morphine it blocked the analgesic effect of morphine. Conversely, clonidine, but not morphine, increased the latency to respond to the aversive stimulation, suggesting that clonidine may not have analgesic properties but may merely impair the ability of the animal to respond to the nociceptive stimulation. Yohimbine produced hyperalgesia and also blocked the effect of morphine. These findings are similar to those seen with dopamine agonists and may be related to the effects of yohimbine on the release of dopamine.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
JournalNeuropharmacology
Volume29
Issue number1
DOIs
StatePublished - Jan 1990
Externally publishedYes

Keywords

  • analgesia
  • clonidine
  • morphine
  • norepinephrine
  • yohimbine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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