Effects of cigarette smoking on erectile dysfunction

Jason R. Kovac, C. Labbate, R. Ramasamy, D. Tang, L. I. Lipshultz

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Cigarette smoking is a leading cause of preventable morbidity and mortality in the United States. Although public policies have resulted in a decreased number of new smokers, smoking rates remain stubbornly high in certain demographics with 20% of all American middle-aged men smoking. In addition to the well-established harmful effects of smoking (i.e. coronary artery disease and lung cancer), the past three decades have led to a compendium of evidence being compiled into the development of a relationship between cigarette smoking and erectile dysfunction. The main physiologic mechanism that appears to be affected includes the nitric oxide signal transduction pathway. This review details the recent literature linking cigarette smoking to erectile dysfunction, epidemiological associations, dose dependency and the effects of smoking cessation on improving erectile quality.

Original languageEnglish (US)
Pages (from-to)1087-1092
Number of pages6
Issue number10
StatePublished - Dec 2015
Externally publishedYes


  • Erectile dysfunction
  • Nitric oxide
  • Smoking
  • Smoking cessation
  • Vascular disease

ASJC Scopus subject areas

  • Endocrinology
  • Urology


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