Axonal transport studies were undertaken to determine the effect of chronic demyelination on axonal function in experimental allergic optic neuritis in the guinea pig, an animal model for multiple sclerosis. Fast and slow components of axonal transport over the prelaminar, laminar, and retrolaminar portions of the optic nerve head and at the foci of demyelination in the retrobulbar optic nerve were evaluated by the autoradiographic grain-counting technique. At 6 hr there was a significant increase in grain counts over the demyelinated foci and in the regions proximal to the demyelination, including the swollen disc. At day 1 there was no significant difference in the grain counts at the site of demyelination when compared to the myelinated portion of the nerve. However, at days 3 and 7 days there was a decrease in the number of grains over the demyelinated areas. These results indicate impairment of axonal function in chronic demyelination. Moreover, in this pathologic process, most of the synthesized materials appear to more in the fast transport phase, unlike in ther normal optic nerve where the bulk of materials move by slow transport.
|Original language||English (US)|
|Number of pages||6|
|Journal||Investigative Ophthalmology and Visual Science|
|State||Published - Jan 1 1981|
ASJC Scopus subject areas
- Sensory Systems
- Cellular and Molecular Neuroscience