Effects of chronic demyelination on axonal transport in experimental allergic optic neuritis

N. A. Rao, J. Guy, P. S. Sheffield

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23 Scopus citations


Axonal transport studies were undertaken to determine the effect of chronic demyelination on axonal function in experimental allergic optic neuritis in the guinea pig, an animal model for multiple sclerosis. Fast and slow components of axonal transport over the prelaminar, laminar, and retrolaminar portions of the optic nerve head and at the foci of demyelination in the retrobulbar optic nerve were evaluated by the autoradiographic grain-counting technique. At 6 hr there was a significant increase in grain counts over the demyelinated foci and in the regions proximal to the demyelination, including the swollen disc. At day 1 there was no significant difference in the grain counts at the site of demyelination when compared to the myelinated portion of the nerve. However, at days 3 and 7 days there was a decrease in the number of grains over the demyelinated areas. These results indicate impairment of axonal function in chronic demyelination. Moreover, in this pathologic process, most of the synthesized materials appear to more in the fast transport phase, unlike in ther normal optic nerve where the bulk of materials move by slow transport.

Original languageEnglish (US)
Pages (from-to)606-611
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Issue number4
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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