Effects of cellular senescence on metabolic pathways in non-immune and immune cells

Daniela Frasca, Yara Bou Saada, Denisse Garcia, Bertrand Friguet

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Many cellular stresses induce cellular senescence and the irreversible arrest of cell proliferation in different cell types. Although blocked in their capacity to divide, senescent cells are metabolically active and are characterized by a different metabolic phenotype as compared to non-senescent cells. Changes observed in senescent cells depend from the cell type and lead to an adaptative flexibility in the type of metabolism. This metabolic reprogramming is needed to cope with survival and with the energetic demands of the senescent program that include the increased secretion of senescence-associated secretory phenotype factors.

Original languageEnglish (US)
Article number111428
JournalMechanisms of Ageing and Development
Volume194
DOIs
StatePublished - Mar 2021

Keywords

  • Cellular senescence
  • Immune cells
  • Metabolism
  • Non-immune cells

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

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