Effects of bleomycin on cells in culture: A quantitative cytochemical study

L. S. Desai; A. Krishan; G. E. Foley

doi:10.1002/1097-0142(197412)34:6<1873::AID-CNCR2820340603>3.0.CO;2-U

Effects of bleomycin on cells in culture: A quantitative cytochemical study

L. S. Desai, A. Krishan, G. E. Foley

Pathology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Bleomycin treated mouse L 929 fibroblasts are large in size and often appear multinucleated. Quantitative cytochemical studies show that these cells have an increased content of DNA and total proteins (dry mass) per cell. The increased accumulation of DNA and protein content (4-8C or more) is compatible with and may well be related to the bleomycin induced inhibition of cell division and the resulting endoreduplication.

Original language	English (US)
Pages (from-to)	1873-1877
Number of pages	5
Journal	Cancer
Volume	34
Issue number	6
DOIs	https://doi.org/10.1002/1097-0142(197412)34:6<1873::AID-CNCR2820340603>3.0.CO;2-U
State	Published - Dec 1974

ASJC Scopus subject areas

Oncology
Cancer Research

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AB - Bleomycin treated mouse L 929 fibroblasts are large in size and often appear multinucleated. Quantitative cytochemical studies show that these cells have an increased content of DNA and total proteins (dry mass) per cell. The increased accumulation of DNA and protein content (4-8C or more) is compatible with and may well be related to the bleomycin induced inhibition of cell division and the resulting endoreduplication.

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Effects of bleomycin on cells in culture: A quantitative cytochemical study

Abstract

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