Abstract
Bleomycin treated mouse L 929 fibroblasts are large in size and often appear multinucleated. Quantitative cytochemical studies show that these cells have an increased content of DNA and total proteins (dry mass) per cell. The increased accumulation of DNA and protein content (4-8C or more) is compatible with and may well be related to the bleomycin induced inhibition of cell division and the resulting endoreduplication.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1873-1877 |
| Number of pages | 5 |
| Journal | Cancer |
| Volume | 34 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1974 |
ASJC Scopus subject areas
- Oncology
- Cancer Research
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Desai, L. S., Krishan, A., & Foley, G. E. (1974). Effects of bleomycin on cells in culture: A quantitative cytochemical study. Cancer, 34(6), 1873-1877. https://doi.org/10.1002/1097-0142(197412)34:6<1873::AID-CNCR2820340603>3.0.CO;2-U