Effects of bleomycin on cells in culture: A quantitative cytochemical study

L. S. Desai, A. Krishan, G. E. Foley

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Bleomycin treated mouse L 929 fibroblasts are large in size and often appear multinucleated. Quantitative cytochemical studies show that these cells have an increased content of DNA and total proteins (dry mass) per cell. The increased accumulation of DNA and protein content (4-8C or more) is compatible with and may well be related to the bleomycin induced inhibition of cell division and the resulting endoreduplication.

Original languageEnglish (US)
Pages (from-to)1873-1877
Number of pages5
JournalCancer
Volume34
Issue number6
DOIs
StatePublished - Dec 1974

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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