Effects of benzalkonium salts on G-protein-mediated processes and surface membranes: Relevance to microbial- and chemical-induced diseases

Roberto Patarca-Montero, Mary Ann Fletcher

Research output: Contribution to journalReview article

Abstract

Benzalkonium salts comprise a group of positively charged surface-active alkylamine biocides with the general formula alkyldimethylbenzylammonium chloride or bromide. They interact with guanine nucleotide triphosphate-binding proteins (G proteins), thereby affecting signal transduction in a variety of cell types and processes. The present report reviews the known and potential basic science research and clinical applications and manifestations of benzalkonium salts. Benzalkonium salts have antiproliferative effects on a variety of cells (including T cells) through G-protein-dependent pathways, affect cytokine gene expression (downregulate tumor necrosis factor expression), and are also effective bactericidal, fungicidal, and virucidal agents with multisite (direct and immunologically-mediated) inhibitory activity against many pathogens, including the human immunodeficiency virus (HIV), papillomavirus, and herpesviruses. Therefore, benzalkonium salts not only appear to be effective as disinfectants and spermicides but may also prove useful in the prevention and treatment of several diseases, particularly those linked to viruses and originating at the skin or mucosal surface. The untoward effects of benzalkonium salts are also discussed as a paradigm for chemical-induced diseases.

Original languageEnglish (US)
Pages (from-to)87-168
Number of pages82
JournalJournal Of Chronic Fatigue Syndrome
Volume10
Issue number3-4
DOIs
StatePublished - Nov 6 2002

Keywords

  • Benzalkonium salts
  • Chronic fatigue syndrome
  • Cytokines
  • Human immunodeficiency virus
  • Natural killer cell cytotoxic activity
  • Neoplasia
  • T-cell proliferation

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

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