Effects of Anticoagulant Medication on Bone-Healing

Alexander J. Butler, Frank J. Eismont

Research output: Contribution to journalArticlepeer-review


»: A substantial proportion of patients undergoing orthopaedic care are prescribed some form of anticoagulant medication, whether for perioperative venous thromboembolism prophylaxis or chronic anticoagulation in the setting of a cardiac or other condition. »: An abundance of preclinical data suggests that many commonly used anticoagulant medications may have a harmful effect on bone-healing. »: The orthopaedic surgeon should be informed and mindful of the added variable that anticoagulation may play in the outcomes of fracture treatment and bone-healing. »: Heparin and warfarin appear to have a greater detrimental impact than low-molecular-weight heparin. Factor Xa inhibitors may confer the least risk, with some studies even suggesting the potential for enhancement of bone-healing.

Original languageEnglish (US)
Pages (from-to)e20.00194
JournalJBJS reviews
Issue number5
StatePublished - May 18 2021

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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