Effects of anticholinergic drugs on regional brain neurotensin concentrations

Beth Levant; Garth Bissette; Charles B. Nemeroff

doi:10.1016/0014-2999(89)90731-0

Effects of anticholinergic drugs on regional brain neurotensin concentrations

Beth Levant, Garth Bissette, Charles B. Nemeroff

Research output: Contribution to journal › Article

11 Scopus citations

Abstract

Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.

Original language	English (US)
Pages (from-to)	327-330
Number of pages	4
Journal	European Journal of Pharmacology
Volume	165
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(89)90731-0
State	Published - Jun 20 1989
Externally published	Yes

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Keywords

Atropine
Caudate nucleus
Haloperidol
Neurotensin
Nucleus accumbens
Scopolamine

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

Cite this

Levant, B., Bissette, G., & Nemeroff, C. B. (1989). Effects of anticholinergic drugs on regional brain neurotensin concentrations. European Journal of Pharmacology, 165(2-3), 327-330. https://doi.org/10.1016/0014-2999(89)90731-0

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10.1016/0014-2999(89)90731-0