Abstract
Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.
Original language | English (US) |
---|---|
Pages (from-to) | 327-330 |
Number of pages | 4 |
Journal | European Journal of Pharmacology |
Volume | 165 |
Issue number | 2-3 |
DOIs | |
State | Published - Jun 20 1989 |
Externally published | Yes |
Keywords
- Atropine
- Caudate nucleus
- Haloperidol
- Neurotensin
- Nucleus accumbens
- Scopolamine
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology