Effects of anticholinergic drugs on regional brain neurotensin concentrations

Beth Levant, Garth Bissette, Charles B. Nemeroff

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.

Original languageEnglish (US)
Pages (from-to)327-330
Number of pages4
JournalEuropean Journal of Pharmacology
Volume165
Issue number2-3
DOIs
StatePublished - Jun 20 1989
Externally publishedYes

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Keywords

  • Atropine
  • Caudate nucleus
  • Haloperidol
  • Neurotensin
  • Nucleus accumbens
  • Scopolamine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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