Effects of anticholinergic drugs on regional brain neurotensin concentrations

Beth Levant; Garth Bissette; Charles B. Nemeroff

doi:10.1016/0014-2999(89)90731-0

Effects of anticholinergic drugs on regional brain neurotensin concentrations

Beth Levant, Garth Bissette, Charles B. Nemeroff

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.

Original language	English (US)
Pages (from-to)	327-330
Number of pages	4
Journal	European Journal of Pharmacology
Volume	165
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(89)90731-0
State	Published - Jun 20 1989
Externally published	Yes

Keywords

Atropine
Caudate nucleus
Haloperidol
Neurotensin
Nucleus accumbens
Scopolamine

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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title = "Effects of anticholinergic drugs on regional brain neurotensin concentrations",

abstract = "Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.",

keywords = "Atropine, Caudate nucleus, Haloperidol, Neurotensin, Nucleus accumbens, Scopolamine",

author = "Beth Levant and Garth Bissette and Nemeroff, {Charles B.}",

note = "Funding Information: Supported by NIMH-39415.",

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language = "English (US)",

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T1 - Effects of anticholinergic drugs on regional brain neurotensin concentrations

AU - Levant, Beth

AU - Bissette, Garth

AU - Nemeroff, Charles B.

N1 - Funding Information: Supported by NIMH-39415.

PY - 1989/6/20

Y1 - 1989/6/20

N2 - Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.

AB - Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.

KW - Atropine

KW - Caudate nucleus

KW - Haloperidol

KW - Neurotensin

KW - Nucleus accumbens

KW - Scopolamine

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Effects of anticholinergic drugs on regional brain neurotensin concentrations

Abstract

Keywords

ASJC Scopus subject areas

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