Effects of anticholinergic drugs on regional brain neurotensin concentrations

Beth Levant; Garth Bissette; Charles B. Nemeroff

doi:10.1016/0014-2999(89)90731-0

Effects of anticholinergic drugs on regional brain neurotensin concentrations

Beth Levant, Garth Bissette, Charles B. Nemeroff

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.

Original language	English (US)
Pages (from-to)	327-330
Number of pages	4
Journal	European Journal of Pharmacology
Volume	165
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(89)90731-0
State	Published - Jun 20 1989
Externally published	Yes

Keywords

Atropine
Caudate nucleus
Haloperidol
Neurotensin
Nucleus accumbens
Scopolamine

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

Access to Document

10.1016/0014-2999(89)90731-0

Cite this

@article{8877c2c4f32c419e9eb7af471d1c30bd,

title = "Effects of anticholinergic drugs on regional brain neurotensin concentrations",

abstract = "Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.",

keywords = "Atropine, Caudate nucleus, Haloperidol, Neurotensin, Nucleus accumbens, Scopolamine",

author = "Beth Levant and Garth Bissette and Nemeroff, {Charles B.}",

note = "Funding Information: Supported by NIMH-39415.",

year = "1989",

month = jun,

day = "20",

doi = "10.1016/0014-2999(89)90731-0",

language = "English (US)",

volume = "165",

pages = "327--330",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

number = "2-3",

}

TY - JOUR

T1 - Effects of anticholinergic drugs on regional brain neurotensin concentrations

AU - Levant, Beth

AU - Bissette, Garth

AU - Nemeroff, Charles B.

N1 - Funding Information: Supported by NIMH-39415.

PY - 1989/6/20

Y1 - 1989/6/20

N2 - Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.

AB - Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.

KW - Atropine

KW - Caudate nucleus

KW - Haloperidol

KW - Neurotensin

KW - Nucleus accumbens

KW - Scopolamine

UR - http://www.scopus.com/inward/record.url?scp=0024375634&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024375634&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(89)90731-0

DO - 10.1016/0014-2999(89)90731-0

M3 - Article

C2 - 2776835

AN - SCOPUS:0024375634

VL - 165

SP - 327

EP - 330

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 2-3

ER -

Effects of anticholinergic drugs on regional brain neurotensin concentrations

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this