Effects of anticholinergic drugs on regional brain neurotensin concentrations

Beth Levant, Garth Bissette, Charles Nemeroff

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.

Original languageEnglish
Pages (from-to)327-330
Number of pages4
JournalEuropean Journal of Pharmacology
Volume165
Issue number2-3
DOIs
StatePublished - Jun 20 1989
Externally publishedYes

Fingerprint

Neurotensin
Cholinergic Antagonists
Atropine
methyl bromide
Caudate Nucleus
Nucleus Accumbens
Antipsychotic Agents
Brain
Pharmaceutical Preparations
Scopolamine Hydrobromide
Haloperidol

Keywords

  • Atropine
  • Caudate nucleus
  • Haloperidol
  • Neurotensin
  • Nucleus accumbens
  • Scopolamine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Effects of anticholinergic drugs on regional brain neurotensin concentrations. / Levant, Beth; Bissette, Garth; Nemeroff, Charles.

In: European Journal of Pharmacology, Vol. 165, No. 2-3, 20.06.1989, p. 327-330.

Research output: Contribution to journalArticle

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