Abstract
Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.
| Original language | English |
|---|---|
| Pages (from-to) | 327-330 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 165 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Jun 20 1989 |
| Externally published | Yes |
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Keywords
- Atropine
- Caudate nucleus
- Haloperidol
- Neurotensin
- Nucleus accumbens
- Scopolamine
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Effects of anticholinergic drugs on regional brain neurotensin concentrations. / Levant, Beth; Bissette, Garth; Nemeroff, Charles.
In: European Journal of Pharmacology, Vol. 165, No. 2-3, 20.06.1989, p. 327-330.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of anticholinergic drugs on regional brain neurotensin concentrations
AU - Levant, Beth
AU - Bissette, Garth
AU - Nemeroff, Charles
PY - 1989/6/20
Y1 - 1989/6/20
N2 - Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.
AB - Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.
KW - Atropine
KW - Caudate nucleus
KW - Haloperidol
KW - Neurotensin
KW - Nucleus accumbens
KW - Scopolamine
UR - http://www.scopus.com/inward/record.url?scp=0024375634&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024375634&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(89)90731-0
DO - 10.1016/0014-2999(89)90731-0
M3 - Article
C2 - 2776835
AN - SCOPUS:0024375634
VL - 165
SP - 327
EP - 330
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2-3
ER -