Abstract
Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 327-330 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 165 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Jun 20 1989 |
| Externally published | Yes |
Keywords
- Atropine
- Caudate nucleus
- Haloperidol
- Neurotensin
- Nucleus accumbens
- Scopolamine
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
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Cite this
Levant, B., Bissette, G., & Nemeroff, C. B. (1989). Effects of anticholinergic drugs on regional brain neurotensin concentrations. European Journal of Pharmacology, 165(2-3), 327-330. https://doi.org/10.1016/0014-2999(89)90731-0