Effects of analogs of (pyro)Glu-His-Gly-OH on food consumption and gastric acid secretion in rats

J. Jaworek; Andrew V Schally; D. H. Coy; J. Colaluca

doi:10.1016/0024-3205(84)90046-8

Effects of analogs of (pyro)Glu-His-Gly-OH on food consumption and gastric acid secretion in rats

J. Jaworek, Andrew V Schally, D. H. Coy, J. Colaluca

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7 Scopus citations

Abstract

The effects of administration of (pyro)Glu-His-Gly-OH and its analogs on food consumption and 2-Deoxy-D-Glucose (2-DG)-induced gastric acid secretion were examined in rats. (Pyro)Glu-His-Gly-OH and (pyro)Glu-His-EA significantly reduced food consumption, but not gastric acid secretion as compared with controls. The tripeptides: (pyro)Glu-3Me-His-Gly-OH, (pyro)Glu-His-D-Ala-OH, and (pyro)Glu-Phe-Gly-OH were found to significantly inhibit 2-DG-induced gastric acid secretion. Our results indicate that some analogs of (pyro)Glu-His-Gly-OH cause a greater inhibition of food consumption or gastric acid secretion in rats than the original tripeptide, in analogy to findings obtained in dogs.

Original language	English
Pages (from-to)	2597-2603
Number of pages	7
Journal	Life Sciences
Volume	34
Issue number	26
DOIs	https://doi.org/10.1016/0024-3205(84)90046-8
State	Published - Jun 25 1984
Externally published	Yes

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ASJC Scopus subject areas

Pharmacology

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Jaworek, J., Schally, A. V., Coy, D. H., & Colaluca, J. (1984). Effects of analogs of (pyro)Glu-His-Gly-OH on food consumption and gastric acid secretion in rats. Life Sciences, 34(26), 2597-2603. https://doi.org/10.1016/0024-3205(84)90046-8

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abstract = "The effects of administration of (pyro)Glu-His-Gly-OH and its analogs on food consumption and 2-Deoxy-D-Glucose (2-DG)-induced gastric acid secretion were examined in rats. (Pyro)Glu-His-Gly-OH and (pyro)Glu-His-EA significantly reduced food consumption, but not gastric acid secretion as compared with controls. The tripeptides: (pyro)Glu-3Me-His-Gly-OH, (pyro)Glu-His-D-Ala-OH, and (pyro)Glu-Phe-Gly-OH were found to significantly inhibit 2-DG-induced gastric acid secretion. Our results indicate that some analogs of (pyro)Glu-His-Gly-OH cause a greater inhibition of food consumption or gastric acid secretion in rats than the original tripeptide, in analogy to findings obtained in dogs.",

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10.1016/0024-3205(84)90046-8