Abstract
The effects of administration of (pyro)Glu-His-Gly-OH and its analogs on food consumption and 2-Deoxy-D-Glucose (2-DG)-induced gastric acid secretion were examined in rats. (Pyro)Glu-His-Gly-OH and (pyro)Glu-His-EA significantly reduced food consumption, but not gastric acid secretion as compared with controls. The tripeptides: (pyro)Glu-3Me-His-Gly-OH, (pyro)Glu-His-D-Ala-OH, and (pyro)Glu-Phe-Gly-OH were found to significantly inhibit 2-DG-induced gastric acid secretion. Our results indicate that some analogs of (pyro)Glu-His-Gly-OH cause a greater inhibition of food consumption or gastric acid secretion in rats than the original tripeptide, in analogy to findings obtained in dogs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2597-2603 |
| Number of pages | 7 |
| Journal | Life Sciences |
| Volume | 34 |
| Issue number | 26 |
| DOIs | |
| State | Published - Jun 25 1984 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
Fingerprint Dive into the research topics of 'Effects of analogs of (pyro)Glu-His-Gly-OH on food consumption and gastric acid secretion in rats'. Together they form a unique fingerprint.
Cite this
Jaworek, J., Schally, A. V., Coy, D. H., & Colaluca, J. (1984). Effects of analogs of (pyro)Glu-His-Gly-OH on food consumption and gastric acid secretion in rats. Life Sciences, 34(26), 2597-2603. https://doi.org/10.1016/0024-3205(84)90046-8