Effects of analogs of (pyro)Glu-His-Gly-OH on food consumption and gastric acid secretion in rats

J. Jaworek; A. V. Schally; D. H. Coy; J. Colaluca

doi:10.1016/0024-3205(84)90046-8

Effects of analogs of (pyro)Glu-His-Gly-OH on food consumption and gastric acid secretion in rats

J. Jaworek, A. V. Schally, D. H. Coy, J. Colaluca

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The effects of administration of (pyro)Glu-His-Gly-OH and its analogs on food consumption and 2-Deoxy-D-Glucose (2-DG)-induced gastric acid secretion were examined in rats. (Pyro)Glu-His-Gly-OH and (pyro)Glu-His-EA significantly reduced food consumption, but not gastric acid secretion as compared with controls. The tripeptides: (pyro)Glu-3Me-His-Gly-OH, (pyro)Glu-His-D-Ala-OH, and (pyro)Glu-Phe-Gly-OH were found to significantly inhibit 2-DG-induced gastric acid secretion. Our results indicate that some analogs of (pyro)Glu-His-Gly-OH cause a greater inhibition of food consumption or gastric acid secretion in rats than the original tripeptide, in analogy to findings obtained in dogs.

Original language	English (US)
Pages (from-to)	2597-2603
Number of pages	7
Journal	Life Sciences
Volume	34
Issue number	26
DOIs	https://doi.org/10.1016/0024-3205(84)90046-8
State	Published - Jun 25 1984
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Effects of analogs of (pyro)Glu-His-Gly-OH on food consumption and gastric acid secretion in rats",

abstract = "The effects of administration of (pyro)Glu-His-Gly-OH and its analogs on food consumption and 2-Deoxy-D-Glucose (2-DG)-induced gastric acid secretion were examined in rats. (Pyro)Glu-His-Gly-OH and (pyro)Glu-His-EA significantly reduced food consumption, but not gastric acid secretion as compared with controls. The tripeptides: (pyro)Glu-3Me-His-Gly-OH, (pyro)Glu-His-D-Ala-OH, and (pyro)Glu-Phe-Gly-OH were found to significantly inhibit 2-DG-induced gastric acid secretion. Our results indicate that some analogs of (pyro)Glu-His-Gly-OH cause a greater inhibition of food consumption or gastric acid secretion in rats than the original tripeptide, in analogy to findings obtained in dogs.",

author = "J. Jaworek and Schally, {A. V.} and Coy, {D. H.} and J. Colaluca",

note = "Funding Information: This work was supported by a grant from Biomeasure, Inc., U.S. Public Health Service Grant AM 07467 (to A.V.S.) and the Medical Research Service of the Veterans Administration. We would like to acknowledge the expert assistance of Mr. Weldon Carter, Mr. David Kraft, Mr. Michael Hurwitz, and Mr. Robert Liljeberg in our experiments. We are deeply grateful to Dr. James Gibbs, M.D., E.W. Bourne Laboratory, the New York Hospital, for his unselfish and valuable advice with animal preparation used for this study.",

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AU - Jaworek, J.

AU - Schally, A. V.

AU - Coy, D. H.

AU - Colaluca, J.

N1 - Funding Information: This work was supported by a grant from Biomeasure, Inc., U.S. Public Health Service Grant AM 07467 (to A.V.S.) and the Medical Research Service of the Veterans Administration. We would like to acknowledge the expert assistance of Mr. Weldon Carter, Mr. David Kraft, Mr. Michael Hurwitz, and Mr. Robert Liljeberg in our experiments. We are deeply grateful to Dr. James Gibbs, M.D., E.W. Bourne Laboratory, the New York Hospital, for his unselfish and valuable advice with animal preparation used for this study.

PY - 1984/6/25

Y1 - 1984/6/25

N2 - The effects of administration of (pyro)Glu-His-Gly-OH and its analogs on food consumption and 2-Deoxy-D-Glucose (2-DG)-induced gastric acid secretion were examined in rats. (Pyro)Glu-His-Gly-OH and (pyro)Glu-His-EA significantly reduced food consumption, but not gastric acid secretion as compared with controls. The tripeptides: (pyro)Glu-3Me-His-Gly-OH, (pyro)Glu-His-D-Ala-OH, and (pyro)Glu-Phe-Gly-OH were found to significantly inhibit 2-DG-induced gastric acid secretion. Our results indicate that some analogs of (pyro)Glu-His-Gly-OH cause a greater inhibition of food consumption or gastric acid secretion in rats than the original tripeptide, in analogy to findings obtained in dogs.

AB - The effects of administration of (pyro)Glu-His-Gly-OH and its analogs on food consumption and 2-Deoxy-D-Glucose (2-DG)-induced gastric acid secretion were examined in rats. (Pyro)Glu-His-Gly-OH and (pyro)Glu-His-EA significantly reduced food consumption, but not gastric acid secretion as compared with controls. The tripeptides: (pyro)Glu-3Me-His-Gly-OH, (pyro)Glu-His-D-Ala-OH, and (pyro)Glu-Phe-Gly-OH were found to significantly inhibit 2-DG-induced gastric acid secretion. Our results indicate that some analogs of (pyro)Glu-His-Gly-OH cause a greater inhibition of food consumption or gastric acid secretion in rats than the original tripeptide, in analogy to findings obtained in dogs.

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Effects of analogs of (pyro)Glu-His-Gly-OH on food consumption and gastric acid secretion in rats

Abstract

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